皮下脂肪坏死婴儿血清1,25 - 二羟维生素D浓度升高。

Elevated 1,25-dihydroxyvitamin D serum concentrations in infants with subcutaneous fat necrosis.

作者信息

Kruse K, Irle U, Uhlig R

机构信息

Department of Pediatrics, University of Lübeck, Bremen-Nord, Federal Republic of Germany.

出版信息

J Pediatr. 1993 Mar;122(3):460-3. doi: 10.1016/s0022-3476(05)83441-9.

DOI:10.1016/s0022-3476(05)83441-9

PMID:8441106

Abstract

Two infants with subcutaneous fat necrosis had hypercalcemia that normalized during glucocorticoid treatment. The combination of hypercalcemia, normal concentration of 25-hydroxyvitamin D, an elevated concentration of 1,25-dihydroxyvitamin D, a suppressed parathyroid hormone level, and low-normal bone turnover indicated abnormal 1,25-dihydroxyvitamin D production with increased intestinal absorption of calcium. Unregulated production of 1,25-dihydroxyvitamin D by the granulomatous cells of fat necrosis may cause hypercalcemia.

摘要

两名患有皮下脂肪坏死的婴儿出现高钙血症，在糖皮质激素治疗期间血钙恢复正常。高钙血症、25-羟基维生素D浓度正常、1,25-二羟基维生素D浓度升高、甲状旁腺激素水平受抑制以及骨转换率略低于正常水平的组合表明，1,25-二羟基维生素D产生异常，肠道对钙的吸收增加。脂肪坏死的肉芽肿细胞不受调控地产生1,25-二羟基维生素D可能导致高钙血症。