Sahni Mitali, Patel Pooja, Muthukumar Akila
Pediatrix Medical Group, Sunrise Children's Hospital, University of Nevada, Las Vegas, NV, USA.
Department of Pediatrics, University of Texas Medical Branch, Galveston, TX, USA.
Case Rep Hematol. 2020 Feb 21;2020:5742394. doi: 10.1155/2020/5742394. eCollection 2020.
Subcutaneous fat necrosis (SFN) is a form of transient panniculitis that presents commonly in infants with a history of perinatal insult, particularly hypothermia. It is characterized by subcutaneous nodules and plaques that appear over bony prominences on cheeks, shoulders, buttock, and thighs. SFN is usually associated with various complications including hypercalcemia, thrombocytopenia, hypertriglyceridemia, and hyperglycemia. We present a unique case of a female infant with a history of maternal chorioamnionitis who presented with SFN at 11 days of life with thrombocytosis. The platelet count decreased during the hospital stay, and thrombocytosis resolved over the course of the next two weeks. She did not have any other hematological or metabolic abnormalities associated with SFN.
Infants with perinatal stress are at increased risk of developing SFN during the first month of life. Infants with a diagnosis of SFN should be monitored closely for various hematological and metabolic abnormalities that can have serious consequences.
皮下脂肪坏死（SFN）是一种短暂性脂膜炎，常见于有围产期损伤史的婴儿，尤其是体温过低的情况。其特征为出现在脸颊、肩部、臀部和大腿等骨隆突处的皮下结节和斑块。SFN通常与多种并发症相关，包括高钙血症、血小板减少、高甘油三酯血症和高血糖。我们报告了一例独特的女婴病例，其母亲有绒毛膜羊膜炎病史，该女婴在出生11天时出现SFN并伴有血小板增多症。住院期间血小板计数下降，血小板增多症在接下来的两周内消退。她没有与SFN相关的任何其他血液学或代谢异常。
有围产期应激的婴儿在出生后第一个月发生SFN的风险增加。诊断为SFN的婴儿应密切监测可能产生严重后果的各种血液学和代谢异常情况。
