Gupta N C, Falk P M, Frank A L, Thorson A M, Frick M P, Bowman B
Division of Nuclear Medicine, Creighton University School of Medicine, Omaha, NE.
Nebr Med J. 1993 Feb;78(2):30-5.
Positron emission tomography (PET) is a unique technique for imaging functional metabolism of normal and diseased tissue. Accelerated rate of glucose metabolism typical of malignant tumor cells can be detected by using fluorine-18 deoxyglucose. In this pilot study, PET FDG imaging was compared to computerized tomography for the pre-operative staging of colorectal carcinoma. We prospectively evaluated 16 patients by simultaneously performing PET FDG and CT imaging for lesions in the liver, colon and rectum. The results were compared to the operative findings in all patients. Twenty tumor sites (lymph nodes 5, colon and rectum 13, liver 2) were found on histology in 16 patients. On comparison with histology, sensitivity, specificity and predictive accuracy for detection of tumor sites were 90%, 66% and 87% with PET as compared to 60%, 100%, and 65% with CT. These findings represent increased sensitivity and predictive accuracy for staging of colorectal carcinoma with PET FDG imaging as compared to CT scanning.
正电子发射断层扫描（PET）是一种用于对正常组织和病变组织的功能代谢进行成像的独特技术。使用氟-18脱氧葡萄糖可以检测到恶性肿瘤细胞典型的葡萄糖代谢加速率。在这项初步研究中，将PET FDG成像与计算机断层扫描用于结直肠癌的术前分期进行了比较。我们通过同时对16例患者的肝脏、结肠和直肠病变进行PET FDG和CT成像，对其进行了前瞻性评估。将结果与所有患者的手术结果进行了比较。16例患者的组织学检查发现了20个肿瘤部位（淋巴结5个、结肠和直肠13个、肝脏2个）。与组织学相比，PET检测肿瘤部位的敏感性、特异性和预测准确性分别为90%、66%和87%，而CT分别为60%、100%和65%。这些结果表明，与CT扫描相比，PET FDG成像在结直肠癌分期方面具有更高的敏感性和预测准确性。
