Sher P P
Clin Chem. 1977;23(4):627-30.
I evaluated the diagnostic value of routinely ordered liver-function tests in 175 biopsy-proven cases of hepatic disease by use of stepwise discriminant analysis. The tests studied-total and "direct" bilirubin, alkaline phosphatase, lactate dehydrogenase, and aspartate aminotransferase-correctly classified 45-73% of cases, depending on the homogeneity of the diagnostic groups. Aspartate aminotransferase and alkaline phosphatase were the best discriminators. When all tests were used in the most homogeneous groups (tumors, cirrhosis, and hepatitis), there was a stepwise improvement in diagnostic accuracy from 51 to 73%.
我通过逐步判别分析评估了常规肝功能检查在175例经活检证实的肝病病例中的诊断价值。所研究的检查项目——总胆红素和“直接”胆红素、碱性磷酸酶、乳酸脱氢酶以及天冬氨酸氨基转移酶——根据诊断组的同质性正确分类了45%至73%的病例。天冬氨酸氨基转移酶和碱性磷酸酶是最佳判别指标。当在最同质的组（肿瘤、肝硬化和肝炎）中使用所有检查项目时，诊断准确性从51%逐步提高到73%。
