Olson W A, Dayton P G, Israili Z H, Pruitt A W
Clin Chem. 1977;23(4):745-8.
We modified the micro-scale spectrophotofluorometric method of Miceli et al. [Biochem. Med. 12, 348 (1975)] for the assay of "apparent" isoniazid (isoniazid acid-lable hydrazones) to improve its clinical application. We also adapted the method for determination of acetyl isoniazid. Data are presented showing how long plasma containing isoniazid may validly be stored. The applicability of the method was demonstrated in studies on children and small animals.
我们改进了米塞利等人[《生物化学医学》12, 348 (1975)]用于测定“表观”异烟肼（酸不稳定腙形式的异烟肼）的微量分光光度荧光法，以改善其临床应用。我们还对该方法进行了调整，用于测定乙酰异烟肼。文中给出的数据表明了含有异烟肼的血浆可以有效储存的时长。该方法的适用性在针对儿童和小动物的研究中得到了验证。
