Strychnopentamine, a potential anticancer agent.
作者信息
Quetin-Leclercq J, Bouzahzah B, Pons A, Greimers R, Angenot L, Bassleer R, Barbason H
机构信息
Laboratoire de Pharmacognosie, Université de Liège, Belgium.
出版信息
Planta Med. 1993 Feb;59(1):59-62. doi: 10.1055/s-2006-959605.
PMID:8441783
Abstract
We analysed the effects of strychnopentamine, an alkaloid isolated from Strychnos usambarensis, on an Ehrlich ascites tumor growing in the mouse after inoculation. Four subcutaneous injections of 1.5 mg strychnopentamine (1 per day) induce a significant decrease of the number of tumor cells and a significant increase of the survival of the treated mice. Observed side effects are partial haemolysis and some liver damage.
摘要
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