Rubies-Prat J, Ras M R, Frison J C, Masdeu S, Bacardi R
Clin Chim Acta. 1977 Feb 15;75(1):117-21. doi: 10.1016/0009-8981(77)90506-x.
The in vitro effect of post-heparin and post-heparin plus post-protamine normal serum on serum lipoprotein X (LP-X) is described. Serum LP-X is cleared after incubation with post-heparin normal serum, and serum LP-X remain unmodified when it is incubated with post-heparin plus post-protamine normal serum. The action of phospholipase A from snake venom on serum LP-X is also studied. A very small quantity of phospholipase is necessary to degrade LP-X and to transform lecithin into lysolecithin. It is concluded that phospholipase seems to be the enzyme that most likely induces the LP-X changes after heparin administration.
本文描述了肝素后血清和肝素后加鱼精蛋白后正常血清对血清脂蛋白X（LP-X）的体外作用。血清LP-X与肝素后正常血清孵育后会被清除，而与肝素后加鱼精蛋白后正常血清孵育时，血清LP-X保持不变。还研究了蛇毒中的磷脂酶A对血清LP-X的作用。降解LP-X并将卵磷脂转化为溶血卵磷脂只需极少量的磷脂酶。得出的结论是，磷脂酶似乎是最有可能在给予肝素后引起LP-X变化的酶。
