Blauth C I, Sönksen P H, Tompkins C V, Bloom S R
Clin Endocrinol (Oxf). 1977 Jan;6(1):17-25. doi: 10.1111/j.1365-2265.1977.tb01992.x.
The hypoglycaemic action of somatostatin was investigated in fasted anaesthetized dogs. An isotopic turnover technique with radioactive D-[2-3H] glucose tracer was used to measure the rates of hepatic production and peripheral utilization of glucose before, during, and after a 60min infusion of 150 mug somatostatin. Plasma concentrations of insulin, glucagon, growth hormone, cortisol and free fatty acids were also measured. Somatostatin infusion caused a fall of plasma glucose demonstrable within 10 min. After 60 min plasma glucose had fallen to 75% of the pre-infusion concentration. Simultaneoulsy the specific activity of the D-[2-3H] glucose increased and calculation of the rates of production and utilization of glucose over 10 min intervals indicated that the mean hepatic production rate of glucose fell to 59% of the pre-infusion rate while the rate of peripheral utilization of glucose fell to 83% of the pre-infusion rate. These results show that the hypoglycaemic action of intravenous somatostatin depends exclusively upon the inhibition of hepatic glucose production. This effect may have been partly due to a fall of plasma glucagon concentration and occurred despite a fall of plasma insulin to less than 1 mu 1(-1).
在禁食麻醉犬中研究了生长抑素的降血糖作用。采用放射性D-[2-³H]葡萄糖示踪剂的同位素周转技术，测量在输注150μg生长抑素60分钟之前、期间和之后肝脏葡萄糖生成率和外周葡萄糖利用率。还测量了胰岛素、胰高血糖素、生长激素、皮质醇和游离脂肪酸的血浆浓度。输注生长抑素导致血浆葡萄糖在10分钟内明显下降。60分钟后，血浆葡萄糖降至输注前浓度的75%。同时，D-[2-³H]葡萄糖的比活性增加，并且以10分钟间隔计算葡萄糖生成率和利用率表明，肝脏葡萄糖平均生成率降至输注前率的59%，而外周葡萄糖利用率降至输注前率的83%。这些结果表明，静脉注射生长抑素的降血糖作用完全取决于对肝脏葡萄糖生成的抑制。这种作用可能部分归因于血浆胰高血糖素浓度的下降，并且尽管血浆胰岛素降至小于1μU/ml仍会发生。
