Altszuler N, Gottlieb B, Hampshire J
Diabetes. 1976 Feb;25(2):116-21. doi: 10.2337/diab.25.2.116.
The interaction of insulin and glucagon during infusion of somatostatin (SRIF), which suppresses secretion of these hormones, was investigated in normal, postabsorptive, concious dogs. Hepatic glucose output (production) and over-all glucose uptake by the tissues was measured with 3-3H-glucose, administered by a priming injection along with a constant infusion. Infusion of SRIF (1.5-5.0 mug/min) for 90 minutes resulted in a moderate hypoglycemia associated with a decrease in glucose production. In some animals glucose production and plasma glucose levels returned to normal before the end of SRIF infusion. Glucose uptake tended to follow plasma glucose levels. Upon termination of SRIF infusion, glucose production and uptake and plasma glucose increased sharply.
在正常、处于吸收后状态且清醒的犬类中，研究了生长抑素（SRIF）输注期间胰岛素和胰高血糖素的相互作用，生长抑素会抑制这些激素的分泌。通过首剂注射并持续输注3-³H-葡萄糖来测量肝脏葡萄糖输出（产生）以及组织对葡萄糖的总体摄取。输注SRIF（1.5 - 5.0微克/分钟）90分钟会导致中度低血糖，并伴有葡萄糖产生减少。在一些动物中，葡萄糖产生和血浆葡萄糖水平在SRIF输注结束前恢复正常。葡萄糖摄取倾向于跟随血浆葡萄糖水平变化。在SRIF输注终止后，葡萄糖产生、摄取以及血浆葡萄糖急剧增加。
