Pugliano F A, Pribitikin E, Adler H J, Saunders J C
Department of Otorhinolaryngology, Head and Neck Surgery, University of Pennsylvania, Philadelphia.
Acta Otolaryngol. 1993 Jan;113(1):18-25. doi: 10.3109/00016489309135761.
The recovery of auditory function at selected intervals following exposure to a 0.9 kHz tone for 48 h at 120 dB SPL is described in neonatal chicks. Evoked potentials recorded from the nucleus magnocellularis were used to measure threshold sensitivity and peak-to-peak response amplitude as a function of stimulus intensity. The relation between evoked-response amplitude and stimulus intensity was nearly linear in control animals. However, at 10 days post exposure, the evoked response in mid-range frequencies showed a severe threshold shift and an abnormally rapid growth in amplitude. At 3 days post exposure, the rate of growth was nearly identical to that measured in control animals and threshold sensitivity showed considerable recovery. Current theories of amplitude-intensity growth and studies of basilar papilla damage and repair following intense sound exposure were applied in the analysis of these results.
本文描述了新生雏鸡在120 dB SPL下暴露于0.9 kHz纯音48小时后，在选定时间间隔内听觉功能的恢复情况。从大细胞神经核记录的诱发电位用于测量阈值敏感性和峰峰值响应幅度与刺激强度的函数关系。在对照动物中，诱发电位幅度与刺激强度之间的关系几乎呈线性。然而，在暴露后10天，中频范围内的诱发电反应出现严重的阈值偏移，且幅度异常快速增长。在暴露后3天，增长速率与对照动物中测量的速率几乎相同，阈值敏感性显示出相当程度的恢复。在对这些结果的分析中应用了当前关于幅度-强度增长的理论以及强声暴露后基底乳头损伤和修复的研究。
