苯巴比妥加重乙醇诱导的脂肪肝。

Accentuation of ethanol-induced fatty liver by phenobarbitone.

Marsh A R, Fraser H S, Breckenridge A, Lewis B, Thompson G R

Clin Sci Mol Med. 1977 Feb;52(2):219-22. doi: 10.1042/cs0520219.

Abstract

Four groups of rats received a liquid formula diet, given alone (control), or supplemented with either ethanol or phenobarbitone, or both together. 2. The ethanol-treated group showed a fall in plasma triglyceride and a rise in liver triglyceride, as compared with the control rats. 3. The phenobarbitone-treated group showed a marked rise in plasma triglyceride but not in liver triglyceride. 4. The group receiving both ethanol and phenobarbitone also showed a rise in plasma triglyceride, but this was accompanied by a striking increase in liver triglyceride. 5. These results suggest that ethanol and phenobarbitone each stimulate triglyceride synthesis but that in addition ethanol has an inhibitory effect on hepatic triglyceride secretion.

摘要

四组大鼠接受流质配方饮食，分别单独给予（对照组），或补充乙醇或苯巴比妥，或两者同时补充。2. 与对照大鼠相比，乙醇处理组血浆甘油三酯下降，肝甘油三酯上升。3. 苯巴比妥处理组血浆甘油三酯显著上升，但肝甘油三酯未上升。4. 同时接受乙醇和苯巴比妥的组血浆甘油三酯也上升，但同时肝甘油三酯显著增加。5. 这些结果表明，乙醇和苯巴比妥各自刺激甘油三酯合成，但此外乙醇对肝甘油三酯分泌有抑制作用。