Jernigan T L, Archibald S, Hesselink J R, Atkinson J H, Velin R A, McCutchan J A, Chandler J, Grant I
San Diego Department of Veterans Affairs Medical Center, CA.
Arch Neurol. 1993 Mar;50(3):250-5. doi: 10.1001/archneur.1993.00540030016007.
Magnetic resonance imaging was used to compare male subjects seropositive for antibody to human immunodeficiency virus type 1 (HIV positive), with and without medical symptoms, with two groups of men who were seronegative (HIV negative). The control subjects included men at high risk for exposure to HIV-1 and those at low risk. None of the HIV-positive subjects met criteria for HIV-associated dementia or had detectable opportunistic brain disease. Quantitative image-analytic techniques were used to estimate volumes of ventricular and cortical cerebrospinal fluid, cerebral white matter, and cortical and subcortical gray matter structures. Relative to low-risk group control subjects and asymptomatic HIV-positive subjects, nondemented but medically symptomatic HIV-positive subjects showed significant increases in cerebrospinal fluid, reduced volume of cerebral white matter, and reduced cerebral gray matter volumes. Unexpectedly, however, some cerebrospinal fluid increases and gray matter volume decreases were present in the seronegative high-risk control subjects as well.
利用磁共振成像技术，对两组血清阴性（HIV阴性）男性以及两组血清阳性（HIV阳性）男性进行比较，血清阳性男性中有医学症状的和没有医学症状的均感染了1型人类免疫缺陷病毒。对照受试者包括有感染HIV-1高风险的男性和低风险的男性。所有HIV阳性受试者均未达到HIV相关痴呆的标准，也未检测出机会性脑部疾病。采用定量图像分析技术来估计脑室和皮质脑脊液、脑白质以及皮质和皮质下灰质结构的体积。与低风险组对照受试者和无症状HIV阳性受试者相比，无痴呆但有医学症状的HIV阳性受试者的脑脊液显著增加，脑白质体积减少，脑灰质体积减少。然而，出乎意料的是，血清阴性的高风险对照受试者中也出现了一些脑脊液增加和灰质体积减少的情况。
