Arnold B, Schönrich G, Hämmerling G J
Division of Somatic Genetics, Tumor Immunology Program, German Cancer Research Center, Heidelberg.
Immunol Today. 1993 Jan;14(1):12-4. doi: 10.1016/0167-5699(93)90317-E.
The establishment and maintenance of self tolerance is based on multiple events in the thymus and periphery, resulting in either deletion of self-reactive T cells or induction of nonresponsiveness. Here, Bernd Arnold and colleagues propose that, depending on the tolerogenic signals, peripheral T cells can reach different levels of tolerance with regard to their capacity for reactivation. In addition, it appears that tolerant T cells are still susceptible to further tolerogenic signals, driving them into a deeper state of tolerance. Thus, induction of T-cell tolerance can be viewed as a multistep mechanism.
自身耐受性的建立和维持基于胸腺和外周的多个事件，导致自身反应性T细胞的缺失或无反应性的诱导。在此，伯恩德·阿诺德及其同事提出，根据致耐受性信号的不同，外周T细胞在重新激活能力方面可达到不同程度的耐受性。此外，耐受性T细胞似乎仍易受进一步的致耐受性信号影响，促使它们进入更深层次的耐受状态。因此，T细胞耐受性的诱导可被视为一种多步骤机制。
