Borgeat A, Fuchs T, Wilder-Smith O, Tassonyi E
Department of Anesthesia, University Hospital of Geneva, Switzerland.
J Clin Anesth. 1993 Jan-Feb;5(1):12-5. doi: 10.1016/0952-8180(93)90081-o.
To investigate the effects of droperidol and nalbuphine on spontaneous movements during induction of anesthesia with propofol in children.
Randomized, double-blind study.
Inpatient ear, nose, and throat (ENT) surgical clinic at the University Hospital of Geneva.
Forty-five children, ages 4 to 12 years, undergoing routine elective ENT surgery.
Children were randomly assigned to receive either nalbuphine 0.1 mg/kg, droperidol 0.025 mg/kg, or isotonic saline 3 minutes before anesthesia induction. Induction was performed with a loading dose of propofol 3 mg/kg.
Spontaneous movements were observed in 33%, 87%, and 100% of patients in the nalbuphine, droperidol, and control groups, respectively. The movements were dystonic and choreiform in nature and were similar in all three groups. The frequency of spontaneous movements was significantly reduced (p < 0.05) in the nalbuphine group as compared with the droperidol and control groups.
Nalbuphine, but not droperidol, decreases the frequency of spontaneous movements induced by propofol during induction of anesthesia in children; neither quality of induction and recovery nor interval between the end of propofol administration and tracheal extubation were modified by nalbuphine as compared with the control group.
探讨氟哌利多和纳布啡对儿童丙泊酚麻醉诱导期间自主运动的影响。
随机双盲研究。
日内瓦大学医院的耳鼻喉科（ENT）住院手术诊所。
45名年龄在4至12岁之间接受常规择期耳鼻喉科手术的儿童。
在麻醉诱导前3分钟，儿童被随机分配接受纳布啡0.1mg/kg、氟哌利多0.025mg/kg或等渗盐水。诱导采用丙泊酚负荷剂量3mg/kg进行。
纳布啡组、氟哌利多组和对照组中分别有33%、87%和100%的患者观察到自主运动。这些运动本质上是张力障碍性和舞蹈样的，在所有三组中相似。与氟哌利多组和对照组相比，纳布啡组自主运动的频率显著降低（p<0.05）。
纳布啡而非氟哌利多可降低儿童麻醉诱导期间丙泊酚诱导的自主运动频率；与对照组相比，纳布啡对诱导和恢复质量以及丙泊酚给药结束至气管拔管的间隔时间均无影响。
