Department of Animal Medicine, Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Department of Animal Medicine, Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil.
Vet Anaesth Analg. 2020 May;47(3):347-355. doi: 10.1016/j.vaa.2020.01.008. Epub 2020 Feb 19.
To compare the propofol infusion rate and cardiopulmonary effects during total intravenous anesthesia with propofol alone and propofol combined with methadone, fentanyl or nalbuphine in domestic chickens undergoing ulna osteotomy.
Prospective, randomized, experiment trial.
A total of 59 healthy Hissex Brown chickens weighing 1.5 ± 0.2 kg.
Anesthesia was induced with propofol (9 mg kg) administered intravenously (IV) and maintained with propofol (1.2 mg kg minute) for 30 minutes. Birds were intubated and supplemented with 100% oxygen through a nonrebreathing circuit under spontaneous ventilation. Thereafter, each animal was randomly assigned to one of four groups: group P, no treatment; group PM, methadone (6 mg kg) intramuscularly (IM); group PN, nalbuphine IM (12.5 mg kg); and group PF, fentanyl IV (30 μg kg loading dose, 30 μg kg hour constant rate infusion). During the osteotomy surgery, the propofol infusion rate was adjusted to avoid movement of birds and provide adequate anesthesia. Pulse rate, invasive blood pressure, respiratory frequency, end-tidal carbon dioxide partial pressure (Pe'CO) and hemoglobin oxygen saturation (SpO) were recorded.
Data were available from 58 chickens. The mean ± standard deviation propofol infusion rate (mg kg minute) for the duration of anesthesia was: group P, 0.81 ± 0.15; group PM, 0.66 ± 0.11; group PN, 0.60 ± 0.14; and group PF, 0.80 ± 0.07. Significant differences were P versus PM (p = 0.042), P versus PN (p = 0.002) and PF versus PN (p = 0.004). Pulse rate, blood pressure and SpO remained acceptable for anesthetized birds with minor differences among groups. Values of Pe'CO >60 mmHg (8 kPa) were observed in all groups.
Methadone and nalbuphine, but not fentanyl, decreased the propofol infusion rate required for anesthesia maintenance, but resulted in no obvious benefit in physiological variables.
比较单独使用丙泊酚和丙泊酚联合美沙酮、芬太尼或纳布啡在进行尺骨切开术的国内鸡中进行全静脉麻醉时的丙泊酚输注率和心肺效应。
前瞻性、随机、实验性试验。
共 59 只健康的 Hissex 棕色鸡，体重 1.5±0.2kg。
静脉注射（IV）9mg/kg 丙泊酚诱导麻醉，维持 30 分钟，输注丙泊酚（1.2mg/kg/min）。鸡插管并通过自主通气的非再呼吸回路用 100%氧气补充。此后，每只动物随机分为四组之一：组 P，无治疗；组 PM，肌肉注射美沙酮（6mg/kg）；组 PN，肌肉注射纳布啡（12.5mg/kg）；组 PF，静脉注射芬太尼（30μg/kg 负荷剂量，30μg/kg 小时恒速输注）。在骨切开术过程中，调整丙泊酚输注率以避免鸡的运动并提供足够的麻醉。记录脉搏率、有创血压、呼吸频率、呼气末二氧化碳分压（Pe'CO）和血红蛋白氧饱和度（SpO）。
58 只鸡的数据可用。麻醉期间平均±标准差丙泊酚输注率（mg/kg/min）为：组 P，0.81±0.15；组 PM，0.66±0.11；组 PN，0.60±0.14；组 PF，0.80±0.07。P 与 PM（p=0.042）、P 与 PN（p=0.002）和 PF 与 PN（p=0.004）之间存在显著差异。脉搏率、血压和 SpO 保持可接受，各组之间差异较小。所有组的 Pe'CO 值均>60mmHg（8kPa）。
美沙酮和纳布啡，但不是芬太尼，降低了维持麻醉所需的丙泊酚输注率，但在生理变量方面没有明显获益。
