Arishima K, Yamamoto M, Takizawa T, Sohmiya H, Eguchi Y, Shiota K
Department of Anatomy II, Azabu University School of Veterinary Medicine, Kanagawa, Japan.
Biol Neonate. 1993;63(1):40-3. doi: 10.1159/000243906.
This study was conducted to determine whether acute alcohol consumption in near-term pregnant rats results in constriction of the fetal ductus arteriosus (DA). Twenty milliliters per kilogram of 30% (v/v) alcohol was administered via a stomach tube 0.5, 2, 4, 6 and 12 h prior to cesarean section and fetal sacrifice, at 1.00 p.m. on the 20th gestational day (day 20.5), in experimental groups A1-A5, respectively. Controls were given water alone. The calibers of the DA and pulmonary artery (PA) were measured using the whole-body freezing method with direct exposure of the DA and PA by shaving the frozen chests of the fetuses. The DA was significantly constricted 30 min after alcohol treatment. The constriction was also observed in groups A2-A4, but not in group A5. The PA was also less markedly but significantly constricted 30 min after alcohol administration, but groups A2-A5 showed normal PA caliber. It is concluded that alcohol has a constrictive effect on the DA when administered close to the end of gestation in the rat.
本研究旨在确定妊娠晚期大鼠急性饮酒是否会导致胎儿动脉导管（DA）收缩。在妊娠第20天（第20.5天）下午1点，分别对实验组A1 - A5的大鼠在剖宫产和处死胎儿前0.5、2、4、6和12小时，通过胃管给予每千克体重20毫升30%（体积/体积）的酒精。对照组仅给予水。采用全身冷冻法，通过刮去胎儿冷冻胸部直接暴露DA和肺动脉（PA），测量DA和PA的管径。酒精处理后30分钟，DA明显收缩。在A2 - A4组也观察到收缩，但A5组未观察到。酒精给药后30分钟，PA也有较轻微但显著的收缩，但A2 - A5组的PA管径正常。结论是，在大鼠妊娠接近末期给药时，酒精对DA有收缩作用。
