母体给予百草枯对大鼠胎儿动脉导管的影响。

Effect of maternal paraquat administration on the fetal ductus arteriosus in the rat.

作者信息

Shirai M, Arishima K, Masaoka T, Takagi H, Yamamoto M, Eguchi Y, Akahori F

机构信息

Department of Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.

出版信息

J Vet Med Sci. 1994 Apr;56(2):413-4. doi: 10.1292/jvms.56.413.

DOI:10.1292/jvms.56.413

PMID:8075240

Abstract

The ductus arteriosus (DA) in the fetal rat was calibrated using a whole-body freezing method, 3 hr after maternal treatment with paraquat at a dose of 25 mg/kg of body weight on days 19-21 of gestation. On days 20 and 21, the DA was significantly constricted. The DA was also significantly constricted on day 19 2/3 but not on day 19 1/2. It is concluded that paraquat has a constrictive effect on the DA and that the onset of this effect occurs in the first half of day 19 of gestation.

摘要

在妊娠第19 - 21天，对孕鼠按25毫克/千克体重的剂量腹腔注射百草枯，3小时后，采用全身冷冻法对胎鼠的动脉导管（DA）进行校准。在第20天和第21天，动脉导管显著收缩。在妊娠第19又2/3天动脉导管也显著收缩，但在第19又1/2天未出现收缩。由此得出结论，百草枯对动脉导管有收缩作用，且这种作用在妊娠第19天的上半叶开始出现。