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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Nielsen P, Düllmann J, Wulfhekel U, Heinrich H C

Abtlg Medizinische Biochemie, Physiologisch-Chemisches Institut, Universitätskrankenhaus Eppendorf, Hamburg, Germany.

Int J Biochem. 1993 Feb;25(2):223-32. doi: 10.1016/0020-711x(93)90010-c.

The feeding of 0.5% (3,5,5-trimethylhexanoyl)ferrocene (TMH-ferrocene) in rats resulted in a severe and progressive liver siderosis (total liver iron, 30 mg/g liver wet weight, after 30 weeks). 2. High concentrations of an iron-rich ferritin (up to 250 mg/l) were detected in serum of heavily iron-loaded rats forming a large fraction of non-transferrin-bound-iron (5000 micrograms/dl in maximum). 3. Ferritin and not haemosiderin was the major iron storage protein in the liver. 4. The total liver iron concentration (from 0.4 to > 30 mg Fe/g wet wt) but not the cytosolic low-molecular-weight-iron fraction (from 0.5 to 2.5 microM) was extremely increased during iron-loading.

给大鼠喂食0.5%（3,5,5-三甲基己酰基）二茂铁（TMH-二茂铁）会导致严重且进行性的肝脏铁沉着症（30周后肝脏总铁含量为30毫克/克肝脏湿重）。2. 在铁负荷严重的大鼠血清中检测到高浓度的富含铁的铁蛋白（高达250毫克/升），其构成了非转铁蛋白结合铁的很大一部分（最高达5000微克/分升）。3. 铁蛋白而非含铁血黄素是肝脏中的主要铁储存蛋白。4. 在铁负荷期间，肝脏总铁浓度（从0.4毫克铁/克湿重增至>30毫克铁/克湿重）极度升高，但胞质低分子量铁组分（从0.5微摩尔至2.5微摩尔）并未升高。

Nielsen P, Düllmann J, Wulfhekel U, Heinrich H C

Abtlg Medizinische Biochemie, Physiologisch-Chemisches Institut, Universitätskrankenhaus Eppendorf, Hamburg, Germany.

Int J Biochem. 1993 Feb;25(2):223-32. doi: 10.1016/0020-711x(93)90010-c.

The feeding of 0.5% (3,5,5-trimethylhexanoyl)ferrocene (TMH-ferrocene) in rats resulted in a severe and progressive liver siderosis (total liver iron, 30 mg/g liver wet weight, after 30 weeks). 2. High concentrations of an iron-rich ferritin (up to 250 mg/l) were detected in serum of heavily iron-loaded rats forming a large fraction of non-transferrin-bound-iron (5000 micrograms/dl in maximum). 3. Ferritin and not haemosiderin was the major iron storage protein in the liver. 4. The total liver iron concentration (from 0.4 to > 30 mg Fe/g wet wt) but not the cytosolic low-molecular-weight-iron fraction (from 0.5 to 2.5 microM) was extremely increased during iron-loading.

给大鼠喂食0.5%（3,5,5-三甲基己酰基）二茂铁（TMH-二茂铁）会导致严重且进行性的肝脏铁沉着症（30周后肝脏总铁含量为30毫克/克肝脏湿重）。2. 在铁负荷严重的大鼠血清中检测到高浓度的富含铁的铁蛋白（高达250毫克/升），其构成了非转铁蛋白结合铁的很大一部分（最高达5000微克/分升）。3. 铁蛋白而非含铁血黄素是肝脏中的主要铁储存蛋白。4. 在铁负荷期间，肝脏总铁浓度（从0.4毫克铁/克湿重增至>30毫克铁/克湿重）极度升高，但胞质低分子量铁组分（从0.5微摩尔至2.5微摩尔）并未升高。