Liebowitz M R
Department of Clinical Psychiatry, Columbia University College of Physicians and Surgeons, New York, N.Y.
J Clin Psychiatry. 1993 Feb;54 Suppl:10-4; discussion 15.
Some forms of anxiety and affective disorder, such as panic disorder and major depression, appear distinct, but frequently symptoms of depression and anxiety occur together. The comorbidity of anxiety and depression not only has implications for the differential diagnosis of the disorder but affects the severity and course of illness and its responsiveness to treatment. The results of studies of atypical depression suggest that this form of depressive illness responds better to monoamine oxidase inhibiting medications than to tricyclic antidepressant agents, and this preferential responsiveness may in fact define the boundaries of atypical depression. The serotonin selective reuptake inhibitor paroxetine seems to have a beneficial effect on symptoms of anxiety and agitation in depressed patients. Further clinical research is needed, however, to determine the best way to manage depression with anxiety and atypical depression.
某些形式的焦虑症和情感障碍，如惊恐障碍和重度抑郁症，看似不同，但抑郁和焦虑症状却常常同时出现。焦虑症和抑郁症的共病不仅对该疾病的鉴别诊断有影响，还会影响疾病的严重程度、病程及其对治疗的反应。非典型抑郁症的研究结果表明，这种形式的抑郁症对单胺氧化酶抑制药物的反应比对三环类抗抑郁药更好，而这种优先反应性实际上可能界定了非典型抑郁症的范围。血清素选择性再摄取抑制剂帕罗西汀似乎对抑郁症患者的焦虑和激动症状有有益影响。然而，还需要进一步的临床研究来确定治疗伴有焦虑症的抑郁症和非典型抑郁症的最佳方法。
