Lydiard R B, Brawman-Mintzer O
Medical University of South Carolina, Institute of Psychiatry, Charleston 29425-0742, USA.
J Clin Psychiatry. 1998;59 Suppl 18:10-7.
Depression and anxiety often coexist. When they co-occur, both anxiety and depression appear to be more severe. Increased morbidity, poorer acute and long-term outcome, increased suicide risk, and increased treatment resistance are associated with comorbid anxiety and depression. The term anxious depression has taken on newer meaning with the changes in the diagnostic system that allow for concurrent diagnosis of anxiety disorders and major depression. Attention to the subtype of both anxiety and depression could have significant effects on treatment choice by the clinician. The authors review some historical aspects of anxious depression and also highlight some of the advances in differential diagnosis and treatment of coexisting depression and anxiety.
抑郁和焦虑常常并存。当它们同时出现时，焦虑和抑郁似乎都更为严重。共病焦虑和抑郁会导致发病率增加、急性和长期预后更差、自杀风险升高以及治疗抵抗性增强。随着诊断系统的变化，“焦虑性抑郁”这一术语有了新的含义，该变化允许对焦虑症和重度抑郁症进行同时诊断。关注焦虑和抑郁的亚型可能会对临床医生的治疗选择产生重大影响。作者回顾了焦虑性抑郁的一些历史方面，并强调了共存的抑郁和焦虑在鉴别诊断和治疗方面的一些进展。
