Westerink B H, Lejeune B, Korf J, Van Praag H M
Eur J Pharmacol. 1977 Mar 21;42(2):179-90. doi: 10.1016/0014-2999(77)90358-2.
3,4-Dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were measured in the corpus striatum, nucleus accumbens and tuberculum olfactorium of the rat brain, 4 antidepressants, 4 anesthetics, dipropylacetate, ethosuximide and metoclopramide induced a rise of DOPAC and HVA levels in the 3 brain regions. No change was observed after carbamazepine, diazepam or propranolol treatment. Combined treatment with a maximally effective dose of haloperidol and morphine, oxotremorine or probenecid produced an additional rise of DOPAC and HVA levels, while no additional rise was seen with chloral hydrate, chlorimipramine, ether, halothane, metoclopramide or sulpiride. The potency of drugs to increase DA metabolism in corpus striatum relative to mesolimbic structures was estimated. Atypical neuroleptics such as sulpiride could be differentiated in this respect from classical neuroleptics such as chlorpromazine, fluphenazine and thioridazine, by their ability to produce a relatively large increase of metabolite levels in the mesolimbic regions. The heterogeneous group of 14 non-neuroleptics however produced regional changes which were very similar to those of the atypical neuroleptics. DA metabolism in mesolimbic regions, in contrast to striatal tissue, seems to respond more to atypical neuroleptics and non-neuroleptics than to typical neuroleptics.
在大鼠脑的纹状体、伏隔核和嗅结节中测定了3,4 -二羟基苯乙酸（DOPAC）和高香草酸（HVA）。4种抗抑郁药、4种麻醉药、二丙乙酸、乙琥胺和甲氧氯普胺可使这3个脑区的DOPAC和HVA水平升高。卡马西平、地西泮或普萘洛尔治疗后未观察到变化。用最大有效剂量的氟哌啶醇与吗啡、氧化震颤素或丙磺舒联合治疗可使DOPAC和HVA水平进一步升高，而水合氯醛、氯米帕明、乙醚、氟烷、甲氧氯普胺或舒必利则未见进一步升高。评估了药物相对于中脑边缘结构增加纹状体中多巴胺代谢的效力。在这方面，非典型抗精神病药如舒必利与经典抗精神病药如氯丙嗪、氟奋乃静和硫利达嗪有所不同，前者能使中脑边缘区域的代谢物水平相对大幅升高。然而，14种非抗精神病药组成的异质组产生的区域变化与非典型抗精神病药非常相似。与纹状体组织相比，中脑边缘区域的多巴胺代谢似乎对非典型抗精神病药和非抗精神病药的反应比对典型抗精神病药的反应更大。
