Lindefors N, Sharp T, Ungerstedt U
Eur J Pharmacol. 1986 Oct 7;129(3):401-4. doi: 10.1016/0014-2999(86)90457-7.
The DOPAC/dopamine and HVA/dopamine ratios in extracted whole tissue were determined to obtain an index of dopaminergic activity in various rat brain regions 24 h following 10 days' treatment with haloperidol (0.5 and 2 mg/kg) or sulpiride (10 and 100 mg/kg). Both neuroleptics caused a reduction in the metabolite/amine ratio in nucl. accumbens but not frontal cortex or substantia nigra. Haloperidol, but not sulpiride significantly reduced the HVA/dopamine ratio in striatum. A region-specific action of neuroleptics on brain dopamine neurons is discussed.
测定提取的全脑组织中3,4-二羟基苯乙酸（DOPAC）/多巴胺和高香草酸（HVA）/多巴胺的比值，以获得在给予氟哌啶醇（0.5和2mg/kg）或舒必利（10和100mg/kg）10天治疗后24小时，各大鼠脑区多巴胺能活性的指标。两种抗精神病药物均导致伏隔核中代谢物/胺比值降低，但额叶皮质或黑质未出现此现象。氟哌啶醇可显著降低纹状体中HVA/多巴胺的比值，而舒必利无此作用。文中讨论了抗精神病药物对脑多巴胺神经元的区域特异性作用。
