Testa N G, Hendry J H
Exp Hematol. 1977 Mar;5(2):136-40.
Repeated whole-body irradiation of adult mice induced hemopoiesis in liver, as shown by the presence of stem cells (CFUS), progenitor cells of granulocytes and macrophages (CFUC) and foci of granulocytic cells. The largest numbers of CFUS (up to 700) were found 24 to 47 days after four doses of 450 rad x-rays given at 24 day intervals and 15-17 days after 2310 rad gamma radiation given at a low dose-rate (70 rad per day). CFUS were still present (although in smaller numbers) up to 210 days after four doses of 375 rad x-rays or 225 rad neutrons. CFUC were also present in liver after four doses of 450 rad x-rays, but their numbers could not be calculated accurately because of the marked inhibitory effect of liver cells on in vitro colony growth. Irradiation with one dose of 450 rad x-rays did not result in the appearance of CFUS in liver, suggesting that hepatic hemopoiesis can be induced by radiation only after repeated or prolonged bone marrow injury.
对成年小鼠进行反复全身照射可诱导肝脏造血，这表现为干细胞（CFUS）、粒细胞和巨噬细胞祖细胞（CFUC）的存在以及粒细胞灶的出现。在以24天的间隔给予四剂450拉德X射线后24至47天，以及在以低剂量率（每天70拉德）给予2310拉德γ射线后15 - 17天，发现了数量最多的CFUS（多达700个）。在给予四剂375拉德X射线或225拉德中子后长达210天，CFUS仍然存在（尽管数量较少）。在给予四剂450拉德X射线后，肝脏中也存在CFUC，但由于肝细胞对体外集落生长有显著抑制作用，其数量无法准确计算。单次给予450拉德X射线照射并未导致肝脏中出现CFUS，这表明只有在反复或长期的骨髓损伤后，辐射才能诱导肝脏造血。
