Rothlind J C, Bylsma F W, Peyser C, Folstein S E, Brandt J
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-7218.
J Nerv Ment Dis. 1993 Mar;181(3):194-9. doi: 10.1097/00005053-199303000-00008.
The present study documents the prevalence of deficits in the ability to carry out a variety of activities of daily living in early Huntington's disease (HD), along with the associated neuropsychological and motor deficits. Eighty patients with HD were assessed with the Huntington's Disease-Activities of Daily Living Questionnaire (HD-ADL). Sixty-seven patients also completed a comprehensive assessment of cognitive and voluntary motor functioning and chorea. The latter measures were correlated with HD-ADL total score and with most HD-ADL items, but not with those items dealing with marital and family relationship adjustment. Findings suggest that psychomotor speed and the ability to regulate attention may be particularly important determinants of everyday functioning in mild HD. Consistent with previously reported observations, this appears to be true even after accounting for individual differences in the severity of chorea and voluntary motor impairment.
本研究记录了早期亨廷顿舞蹈症（HD）患者在进行各种日常生活活动时能力缺陷的患病率，以及相关的神经心理学和运动功能缺陷。采用亨廷顿舞蹈症日常生活活动问卷（HD - ADL）对80例HD患者进行评估。67例患者还完成了认知、自主运动功能和舞蹈症的综合评估。后几项测量与HD - ADL总分及大多数HD - ADL项目相关，但与涉及婚姻和家庭关系调适的项目无关。研究结果表明，精神运动速度和注意力调节能力可能是轻度HD患者日常功能的特别重要的决定因素。与先前报道的观察结果一致，即使在考虑了舞蹈症严重程度和自主运动障碍的个体差异之后，情况似乎依然如此。
