Sheppard David P, Pirogovsky-Turk Eva, Woods Steven Paul, Holden Heather M, Nicoll Diane R, Filoteo J Vincent, Corey-Bloom Jody, Gilbert Paul E
a Department of Psychology , University of Houston , Houston , Texas , USA.
b Department of Psychology , San Diego State University , San Diego , California , USA.
Appl Neuropsychol Adult. 2017 Mar-Apr;24(2):176-182. doi: 10.1080/23279095.2015.1125904. Epub 2016 Apr 14.
One important limitation of prior studies examining functional decline in Huntington's disease (HD) has been the reliance on self-reported measures of ability. Since report-based methods can be biased by lack of insight, depression, and cognitive impairment, contrasting self-reported ability with measures that assess capacity may lead to a more comprehensive estimation of real-world functioning. The present study examined self-reported ability to perform instrumental activities of daily living (iADLs) and performance-based financial management capacity in 20 patients diagnosed with mild-moderate Huntington's disease (HD) and 20 demographically similar healthy adults. HD patients reported significantly greater declines in their ability to manage finances. On the capacity measure of financial management, HD patients performed significantly below healthy adults. Additionally, in the HD group there were no significant correlations between self-reported ability and capacity measures of financial management. HD patients endorsed declines in global iADL ability and exhibited deficits in functional capacity when performing a financial management task. Capacity measures may aid in assessing the extent to which HD patients accurately estimate real-world iADL performance, and the present findings suggest that such measures of capacity may be related to the cognitive, but not motor or affective, symptoms of HD.
先前关于亨廷顿舞蹈症（HD）功能衰退的研究存在一个重要局限，即依赖自我报告的能力测量方法。由于基于报告的方法可能因缺乏洞察力、抑郁和认知障碍而产生偏差，将自我报告的能力与评估能力的测量方法进行对比，可能会对现实生活中的功能做出更全面的估计。本研究调查了20名被诊断为轻中度亨廷顿舞蹈症（HD）的患者以及20名人口统计学特征相似的健康成年人自我报告的日常生活工具性活动（iADL）能力和基于表现的财务管理能力。HD患者报告称其财务管理能力下降幅度显著更大。在财务管理能力测量方面，HD患者的表现明显低于健康成年人。此外，在HD组中，自我报告的能力与财务管理能力测量之间没有显著相关性。HD患者认可整体iADL能力下降，并且在执行财务管理任务时表现出功能能力缺陷。能力测量可能有助于评估HD患者准确估计现实生活中iADL表现的程度，目前的研究结果表明，这种能力测量可能与HD的认知症状有关，但与运动或情感症状无关。
