Dittrich M, Melichar L, Smetanováa V
Faculty of Pharmacy, Charles University, Department of Pharmaceutical Technology, Hradec Králové, Czechoslovakia.
J Microencapsul. 1993 Jan-Mar;10(1):45-54. doi: 10.3109/02652049309015311.
Influence of total surface area of core material on yield of deposited coacervate was evaluated. A simple coacervation method was employed solvent-evaporation method were used as a model core substance. A mixed polymer system--aqueous solution of gelatin and potassium salt of cellulose acetate phthalate--was used as a wall material. A sodium sulphate solution acted as a desolvating agent. Results obtained clearly show an opposite effect of the size of core material and derived total surface area on the yield of attached coacervate. While keeping the amount of core material constant, the amount of deposited coacervate increased both with the decreased size of core particles (increased total surface area), and increased concentration of desolvating agent. The proportion of wall material gradually increases with the increased concentration of sodium sulphate solution in the range from 1 to 9 per cent of the weight of microcapsules. Analysis of variance was used for the evaluation of obtained data.
评估了核心材料的总表面积对沉积凝聚层产率的影响。采用简单凝聚法,以溶剂蒸发法作为模型核心物质。使用明胶水溶液和邻苯二甲酸醋酸纤维素钾盐的混合聚合物体系作为壁材。硫酸钠溶液用作去溶剂化剂。所得结果清楚地表明,核心材料的尺寸及其衍生的总表面积对附着凝聚层的产率具有相反的影响。在保持核心材料量恒定的情况下,沉积凝聚层的量随着核心颗粒尺寸的减小(总表面积增加)和去溶剂化剂浓度的增加而增加。壁材的比例随着硫酸钠溶液浓度在微胶囊重量的1%至9%范围内增加而逐渐增加。使用方差分析来评估所得数据。