缓释制剂的体外-体内相关性
In vitro-in vivo correlation for modified-release formulations.
作者信息
Drewe J, Guitard P
机构信息
Department of Anesthesia, University Hospital, University of Basel/Kantonsspital, Switzerland.
出版信息
J Pharm Sci. 1993 Feb;82(2):132-7. doi: 10.1002/jps.2600820204.
PMID:8445524
Abstract
A correlation of in vitro dissolution rate measurements with in vivo pharmacokinetic results in a human study was obtained for a sustained-release formulation of bromocriptine. Different methods were applied to reach this correlation, and the various outcomes were compared.
摘要
针对溴隐亭缓释制剂，在一项人体研究中获得了体外溶出速率测量值与体内药代动力学结果之间的相关性。采用了不同方法来达成这种相关性，并对各种结果进行了比较。
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