Ramírez-Amador V, González M, de la Rosa E, Esquivel L, Volkow P, Ochoa F J, Meneses A, Mohar A
Department of Health Care, Universidad Autónoma Metropolitana-Xochimilco, Mexico City, Mexico.
J Oral Pathol Med. 1993 Feb;22(2):87-91. doi: 10.1111/j.1600-0714.1993.tb00050.x.
Oral findings of 42 Mexican AIDS patients with cancer were reviewed. Kaposi's sarcoma (KS) was the most frequent malignancy (81%) followed by non-Hodgkin's lymphoma (NHL) (12%). All cases of NHL were of high or intermediate grade and most of them were extranodal. Out of the 34 individuals with KS, 22 (65%) showed oral KS and in 21 of them the palate was involved. The clinical features of oral KS including site, appearance and size are described. Pseudomembranous candidosis (PC), hairy leukoplakia (HL) and exfoliative cheilitis (ECh) were also found in these patients. There was no association of these lesions with any type of cancer. A strong association of oral candidosis and history of this infection was found, RR = 7.0 (1.3-4.1). There was evidence of severe immunosuppression in most patients, with mean average CD4 counts of 116 mm3 (range 4-841/mm3). Oral KS, ECh, PC and HL were more common in patients with lower CD4 counts. Our findings illustrate the most frequent oral lesions associated with HIV-1 infection in patients with AIDS and cancer, and further support the importance of oral examination in HIV infected patients.
对42例患有癌症的墨西哥艾滋病患者的口腔检查结果进行了回顾。卡波西肉瘤（KS）是最常见的恶性肿瘤（81%），其次是非霍奇金淋巴瘤（NHL）（12%）。所有NHL病例均为高分级或中分级，且大多数为结外病变。在34例患有KS的患者中，22例（65%）出现口腔KS，其中21例累及腭部。描述了口腔KS的临床特征，包括部位、外观和大小。这些患者还发现了假膜性念珠菌病（PC）、毛状白斑（HL）和剥脱性唇炎（ECh）。这些病变与任何类型的癌症均无关联。发现口腔念珠菌病与该感染病史之间存在强关联，相对危险度（RR）=7.0（1.3 - 4.1）。大多数患者有严重免疫抑制的证据，平均CD4细胞计数为116/mm³（范围4 - 841/mm³）。口腔KS、ECh、PC和HL在CD4细胞计数较低的患者中更为常见。我们的研究结果说明了艾滋病和癌症患者中与HIV - 1感染相关的最常见口腔病变，并进一步支持了对HIV感染患者进行口腔检查的重要性。
