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作为环境污染物的硝酸盐肥料:单位面积使用的硝酸盐(硝酸钠和硝酸钾)与胃癌死亡率之间的正相关关系。

Nitrate fertilizers as environmental pollutants: positive correlation between nitrates (NaNO3 and KNO3) used per unit area and stomach cancer mortality rates.

作者信息

Zaldívar R

出版信息

Experientia. 1977 Feb 15;33(2):264-5. doi: 10.1007/BF02124102.

DOI:10.1007/BF02124102
PMID:844585
Abstract

Since a significant positive correlation between nitrate fertilizer exposure and stomach cancer mortality has been found, a study of nitrate fertilizer pollution in arable land in terms of amount of nitrates used per unit area (kg/ha) and stomach cancer death rates was carried out. The regression of death rates for stomach cancer, standardized for age, on the nitrates used per unit area, by province (N = 25), exhibited a significant association between the 2 variables (p less than 0.004). When industrialized provinceds (N = 3) were not considered, a highly significant association was found (F = 16.47; d.f. = 1, 20; p less than 0.0006). The correlation coefficient was + 0.672.

摘要

由于已发现硝酸盐肥料暴露与胃癌死亡率之间存在显著正相关,因此开展了一项关于耕地中硝酸盐肥料污染的研究,研究内容涉及单位面积硝酸盐使用量(千克/公顷)与胃癌死亡率。按省份(N = 25)对年龄标准化后的胃癌死亡率与单位面积硝酸盐使用量进行回归分析,结果显示这两个变量之间存在显著关联(p < 0.004)。若不考虑工业化省份(N = 3),则发现存在高度显著的关联(F = 16.47;自由度 = 1, 20;p < 0.0006)。相关系数为 + 0.672。

相似文献

1
Nitrate fertilizers as environmental pollutants: positive correlation between nitrates (NaNO3 and KNO3) used per unit area and stomach cancer mortality rates.作为环境污染物的硝酸盐肥料:单位面积使用的硝酸盐(硝酸钠和硝酸钾)与胃癌死亡率之间的正相关关系。
Experientia. 1977 Feb 15;33(2):264-5. doi: 10.1007/BF02124102.
2
Further evidence of a positive correlation between exposure to nitrate fertilizers (NaNO3 and KNO3) and gastric cancer death rates: nitrites and nitrosamines.接触硝酸盐肥料(硝酸钠和硝酸钾)与胃癌死亡率之间存在正相关的进一步证据:亚硝酸盐和亚硝胺。
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引用本文的文献

1
Decreasing the NO3 and increasing the vitamin C contents in spinach by a nitrogen deprivation method.通过氮素剥夺法降低菠菜中的硝酸盐含量并提高维生素C含量。
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Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment.哺乳动物硝酸盐的生物合成:内毒素处理可增强15NH3掺入硝酸盐的过程。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4518-21. doi: 10.1073/pnas.80.14.4518.
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Nitrate biosynthesis in the rat. Precursor-product relationships with respect to ammonia.

本文引用的文献

1
Stomach cancer. Positive association with suspended particulate air pollution.
Arch Environ Health. 1969 Apr;18(4):544-7. doi: 10.1080/00039896.1969.10665450.
2
High incidence of gastric carcinoma in a coal mining region.
Cancer. 1972 Mar;29(3):733-7. doi: 10.1002/1097-0142(197203)29:3<733::aid-cncr2820290329>3.0.co;2-4.
3
Epidemiological investigation on stomach cancer mortality in Chileans: association with nitrate fertilizer.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1973 Dec 28;80(4):289-95. doi: 10.1007/BF00284363.
4
Geographic pathology of oral, esophageal, gastric, and intestinal cancer in Chile.
Z Krebsforsch. 1970 Nov 20;75(1):1-13. doi: 10.1007/BF00524739.
大鼠体内硝酸盐的生物合成。与氨相关的前体-产物关系。
Biochem J. 1985 Dec 1;232(2):547-51. doi: 10.1042/bj2320547.
4
Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.哺乳动物硝酸盐生物合成:小鼠巨噬细胞在响应大肠杆菌脂多糖时产生亚硝酸盐和硝酸盐。
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7738-42. doi: 10.1073/pnas.82.22.7738.
5
Nitrate nitrogen levels in drinking water of urban areas with high- and low-risk populations for stomach cancer: an environmental epidemiology study.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 Oct 30;92(3):227-34. doi: 10.1007/BF00461645.
6
A note on the use of nitrate fertilizers in a high-risk geographical area for stomach cancer.
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1978 Sep 28;92(2):215-6. doi: 10.1007/BF00312410.
5
Further evidence of a positive correlation between exposure to nitrate fertilizers (NaNO3 and KNO3) and gastric cancer death rates: nitrites and nitrosamines.接触硝酸盐肥料(硝酸钠和硝酸钾)与胃癌死亡率之间存在正相关的进一步证据:亚硝酸盐和亚硝胺。
Experientia. 1975 Nov 15;31(11):1354-5. doi: 10.1007/BF01945823.