哺乳动物硝酸盐的生物合成：内毒素处理可增强15NH3掺入硝酸盐的过程。
Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment.
作者信息
Wagner D A, Young V R, Tannenbaum S R
出版信息
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4518-21. doi: 10.1073/pnas.80.14.4518.
Abstract
Incorporation of an oral dose of [15N]ammonium acetate into urinary [15N]nitrate has been demonstrated in the rat. Investigation of the regulation of nitrate synthesis has shown that Escherichia coli lipopolysaccharide potently stimulates urinary nitrate excretion (9-fold increase). It was further shown that the enhanced rate of nitrate excretion by lipopolysaccharide was due not to a reduction in nitrate metabolic loss but rather to an increased rate of synthesis. This conclusion was based on finding a proportionally increased incorporation of [15N]ammonium into nitrate nitrogen with lipopolysaccharide treatment. Nitrate biosynthesis was also increased by intraperitoneal injection of carrageenan and subcutaneous injection of turpentine. It is proposed that the pathway of nitrate biosynthesis may be the result of oxidation of reduced nitrogen compounds by oxygen radicals generated by an activated reticuloendothelial system.
摘要
已证实大鼠口服[15N]醋酸铵后，其尿液中的[15N]硝酸盐会有所增加。对硝酸盐合成调节的研究表明，大肠杆菌脂多糖能有效刺激尿液硝酸盐排泄（增加9倍）。进一步研究表明，脂多糖使硝酸盐排泄率提高并非由于硝酸盐代谢损失减少，而是合成速率增加所致。这一结论是基于发现脂多糖处理后[15N]铵向硝酸盐氮的掺入量成比例增加。腹腔注射角叉菜胶和皮下注射松节油也会使硝酸盐生物合成增加。有人提出，硝酸盐生物合成途径可能是活化的网状内皮系统产生的氧自由基氧化还原态氮化合物的结果。
相似文献
1
Mammalian nitrate biosynthesis: incorporation of 15NH3 into nitrate is enhanced by endotoxin treatment.哺乳动物硝酸盐的生物合成：内毒素处理可增强15NH3掺入硝酸盐的过程。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4518-21. doi: 10.1073/pnas.80.14.4518.
2
Mammalian nitrate biochemistry: metabolism and endogenous synthesis.哺乳动物硝酸盐生物化学：代谢与内源性合成
IARC Sci Publ. 1984(57):247-53.
3
Nitrate biosynthesis in the rat. Precursor-product relationships with respect to ammonia.大鼠体内硝酸盐的生物合成。与氨相关的前体-产物关系。
Biochem J. 1985 Dec 1;232(2):547-51. doi: 10.1042/bj2320547.
4
Nitrate biosynthesis in rats, ferrets and humans. Precursor studies with L-arginine.大鼠、雪貂和人类体内硝酸盐的生物合成。L-精氨酸的前体研究。
Carcinogenesis. 1990 May;11(5):855-8. doi: 10.1093/carcin/11.5.855.
5
Influence of dietary protein and gut microflora on endogenous synthesis of nitrate induced by bacterial endotoxin in the rat.膳食蛋白质和肠道微生物群对大鼠细菌内毒素诱导的内源性硝酸盐合成的影响。
Food Chem Toxicol. 1991 Jun;29(6):387-90. doi: 10.1016/0278-6915(91)90078-l.
6
Oxidation of ammonia and hydroxylamine to nitrate in the rat.大鼠体内氨和羟胺氧化为硝酸盐的过程。
IARC Sci Publ. 1984(57):241-6.
7
Effects of Escherichia coli lipopolysaccharide on nitrate synthesis and on nitrosation of proline in rats.大肠杆菌脂多糖对大鼠硝酸盐合成及脯氨酸亚硝化作用的影响。
Food Chem Toxicol. 1990 Aug;28(8):547-51. doi: 10.1016/0278-6915(90)90154-f.
8
Decrease of nitrate biosynthesis in scorbutic mutant rats unable to synthesize ascorbic acid.无法合成抗坏血酸的坏血病突变大鼠中硝酸盐生物合成的减少。
Life Sci. 1990;46(17):1249-54. doi: 10.1016/0024-3205(90)90500-q.
9
Evidence for a synergistic interaction between cadmium and endotoxin toxicity and for nitric oxide and cadmium displacement of metals in the kidney.镉与内毒素毒性之间协同相互作用以及肾脏中一氧化氮和镉对金属的置换作用的证据。
Nitric Oxide. 2000 Aug;4(4):431-40. doi: 10.1006/niox.2000.0295.
10
Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.哺乳动物硝酸盐生物合成：小鼠巨噬细胞在响应大肠杆菌脂多糖时产生亚硝酸盐和硝酸盐。
Proc Natl Acad Sci U S A. 1985 Nov;82(22):7738-42. doi: 10.1073/pnas.82.22.7738.
引用本文的文献
1
Commentary of the SKLM to the EFSA opinion on risk assessment of N-nitrosamines in food.SKLM 对 EFSA 关于食品中 N-亚硝胺风险评估意见的评论。
Arch Toxicol. 2024 Jun;98(6):1573-1580. doi: 10.1007/s00204-024-03726-1. Epub 2024 Apr 4.
2
In Vitro Anti-Inflammatory Effects of Buch.-Ham. Ex D. Don Extract via Blockage of the NF-κB/JNK Signaling Pathways in LPS-Activated Microglial Cells.通过阻断脂多糖激活的小胶质细胞中NF-κB/JNK信号通路研究布氏钩藤提取物的体外抗炎作用
Plants (Basel). 2022 Nov 14;11(22):3095. doi: 10.3390/plants11223095.
3
Salivary nitrate/nitrite and acetaldehyde in humans: potential combination effects in the upper gastrointestinal tract and possible consequences for the in vivo formation of N-nitroso compounds-a hypothesis.人体中的唾液硝酸盐/亚硝酸盐与乙醛：对上消化道的潜在联合作用及对体内N-亚硝基化合物形成的可能影响——一项假说
Arch Toxicol. 2022 Jun;96(6):1905-1914. doi: 10.1007/s00204-022-03296-0. Epub 2022 May 4.
4
Revisiting Nitric Oxide Signaling: Where Was It, and Where Is It Going?重新审视一氧化氮信号：它曾在何处，又将去往何方？
Biochemistry. 2021 Nov 23;60(46):3491-3496. doi: 10.1021/acs.biochem.1c00276. Epub 2021 Jun 7.
5
MicroRNA: Dynamic Regulators of Macrophage Polarization and Plasticity.微小RNA：巨噬细胞极化与可塑性的动态调节因子
Front Immunol. 2017 Aug 31;8:1062. doi: 10.3389/fimmu.2017.01062. eCollection 2017.
6
N (G) ,N (G) -Dimethyl-L-arginine, a dominant precursor of endogenous dimethylamine in rats.N(G),N(G)-二甲基-L-精氨酸，大鼠体内内源性二甲胺的主要前体。
Amino Acids. 1994 Oct;6(3):273-82. doi: 10.1007/BF00813747.
7
Profile of Michael A. Marletta.迈克尔·A·马莱塔简介。
Proc Natl Acad Sci U S A. 2010 Jun 29;107(26):11666-8. doi: 10.1073/pnas.1007505107. Epub 2010 Jun 21.
8
Argatroban increases nitric oxide levels in patients with peripheral arterial obstructive disease: placebo-controlled study.阿加曲班可提高外周动脉阻塞性疾病患者的一氧化氮水平：安慰剂对照研究。
J Thromb Thrombolysis. 1999 Aug;8(2):131-7. doi: 10.1023/a:1008963118789.
9
Arginine metabolism: nitric oxide and beyond.精氨酸代谢：一氧化氮及其他
Biochem J. 1998 Nov 15;336 ( Pt 1)(Pt 1):1-17. doi: 10.1042/bj3360001.
10
Nitric oxide production in critically ill patients.危重症患者一氧化氮的生成
Arch Dis Child. 1996 Jun;74(6):482-9. doi: 10.1136/adc.74.6.482.
本文引用的文献
1
Adaptive characteristics of urea cycle enzymes in the rat.大鼠尿素循环酶的适应性特征
J Biol Chem. 1962 Feb;237:459-68.
2
Animal Species in which N-nitroso compounds induce cancer.N-亚硝基化合物可诱发癌症的动物物种。
Int J Cancer. 1981;27(4):471-4. doi: 10.1002/ijc.2910270408.
3
Evaluation of nitrate synthesis by intestinal microorganisms in vivo.体内肠道微生物硝酸盐合成的评估。
Science. 1981 Jul 24;213(4506):449-50. doi: 10.1126/science.7244641.
4
Reevaluation of nitrate and nitrite levels in the human intestine.人体肠道中硝酸盐和亚硝酸盐水平的重新评估。
Cancer Res. 1981 Jun;41(6):2280-3.
5
Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids.生物体液中硝酸盐、亚硝酸盐和[15N]硝酸盐的分析。
Anal Biochem. 1982 Oct;126(1):131-8. doi: 10.1016/0003-2697(82)90118-x.
6
Blood nitrates and infantile methemoglobinemia.血液硝酸盐与婴儿高铁血红蛋白血症
Clin Chim Acta. 1982 Oct 27;125(2):107-15. doi: 10.1016/0009-8981(82)90187-5.
7
Origin of excess urinary nitrate in the rat.大鼠尿中过量硝酸盐的来源。
Cancer Res. 1982 Sep;42(9):3654-8.
8
Distribution of 13N following intravenous injection of [13N]ammonia in the rat.大鼠静脉注射[13N]氨后13N的分布情况。
Can J Physiol Pharmacol. 1982 Jan;60(1):60-7. doi: 10.1139/y82-008.
9
Nitrate biosynthesis in man.人体中的硝酸盐生物合成
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7764-8. doi: 10.1073/pnas.78.12.7764.
Zotero 插件