Schmid H, Hauffa B P
Universitätsklinikum Essen, Abteilung für pädiatrische Endokrinologie.
Klin Padiatr. 1993 Jan-Feb;205(1):59-63. doi: 10.1055/s-2007-1025199.
Slipped capital femoral epiphysis is a rare complication of growth hormone therapy. We report on a young man with pituitary insufficiency, diagnosed and treated with growth hormone at the age of 14 9/12. The patient withdrew from treatment after 6 months of growth hormone therapy without significant catch-up growth or complications. At the age of 21 8/12 years slipping of the left femoral capital epiphysis became apparent 2 1/2 months after treatment with growth hormone had been resumed in combination with low dose testosterone. Young adult patients with unfused epiphyses undergoing growth hormone substitution should be informed that pain in the lower extremities during therapy may be an important sign of a complication of growth hormone therapy. In this age group, patients complaining of pain in the limb should alert the physician to the possibility that a slipped capital femoral epiphysis may be present.
股骨头骨骺滑脱是生长激素治疗的一种罕见并发症。我们报告一名患有垂体功能不全的年轻男性，他在14岁9/12时被诊断并接受生长激素治疗。该患者在接受生长激素治疗6个月后停止治疗，未出现显著的追赶生长或并发症。在21岁8/12岁时，在重新开始生长激素治疗并联合低剂量睾酮治疗2个半月后，左股骨头骨骺滑脱明显。正在接受生长激素替代治疗的未融合骨骺的年轻成年患者应被告知，治疗期间下肢疼痛可能是生长激素治疗并发症的重要迹象。在这个年龄组中，抱怨肢体疼痛的患者应提醒医生可能存在股骨头骨骺滑脱。
