Inui K, Schäfers H J, Aoki M, Becker V, Ongsiek B, Kemnitz J, Haverich A, Borst H G
Department of Pathology, Hannover Medical School, Germany.
J Thorac Cardiovasc Surg. 1993 Mar;105(3):474-8; discussion 478-9.
The effect of corticosteroids on bronchial healing after modified left lung transplantation was investigated in pigs. In groups I (n = 6) and II (n = 6), animals received cyclosporine (15 mg/kg per day) and azathioprine (2 mg/kg per day). In group II, prednisolone (1 mg/kg per day) was also administered. Bronchial blood flow was estimated at the donor carina and donor second carina with laser Doppler velocimetry and radioisotopes 7 days postoperatively; macroscopic and microscopic assessments of graft airways were performed. Bronchial blood was calculated relative to the recipient carina. In group II, bronchial blood flow at the donor carina and donor second carina was significantly higher than that of group I. Macroscopic assessment revealed more pronounced ischemic changes in group I (5 of 6 animals) than in group II (2 of 6 animals, p = not significant). Microscopically, airway samples from the donor carina revealed marked destructive changes in five of six animals in group I. In group II, only mild ischemic changes, which were limited to the respiratory epithelium, were seen. We concluded that the administration of prednisolone results in improved bronchial blood flow and decreased bronchial ischemia after lung transplantation.
在猪身上研究了皮质类固醇对改良左肺移植后支气管愈合的影响。在第一组（n = 6）和第二组（n = 6）中，动物接受环孢素（每天15 mg/kg）和硫唑嘌呤（每天2 mg/kg）。在第二组中，还给予泼尼松龙（每天1 mg/kg）。术后7天，用激光多普勒测速仪和放射性同位素在供体隆突和供体第二隆突处估计支气管血流；对移植气道进行宏观和微观评估。计算相对于受体隆突的支气管血流量。在第二组中，供体隆突和供体第二隆突处的支气管血流明显高于第一组。宏观评估显示，第一组（6只动物中的5只）的缺血变化比第二组（6只动物中的2只，p =无显著性差异）更明显。在显微镜下，来自供体隆突的气道样本显示，第一组6只动物中有5只出现明显的破坏性变化。在第二组中，仅见轻度缺血变化，仅限于呼吸道上皮。我们得出结论，泼尼松龙的给药可改善肺移植后的支气管血流并减少支气管缺血。
