Lipartiti M, Fadda E, Savoini G, Siliprandi R, Sautter J, Arban R, Manev H
Fidia Research Laboratories, Abano Terme (PD), Italy.
Life Sci. 1993;52(10):PL85-90. doi: 10.1016/0024-3205(93)90522-5.
The effect of intrahippocampal (i.h.) and intraocular (i.o.) administration of the selective metabotropic glutamate receptor (mGluR) agonist (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) was studied in different rat strains. A massive hippocampal damage was observed in CD/SD and Fischer 344 but not in SD/Rij and Brown Norway rats 7 days following the i.h. injection of 1S,3R-ACPD, while no retinal damage was observed following its i.o. administration. Moreover, 1S,3R-ACPD reduced the N-methyl-D-aspartate (NMDA) toxicity in the retina of both CD/SD and SD/Rij rats. Regardless of its toxic action on hippocampal neurons the i.h. injection of 1S,3R-ACPD caused an acute stimulation of motor activity in both CD/SD and SD/Rij rats. This effect was blocked by the intracerebroventricular (i.c.v.) administration of the putative mGluR antagonist L-2-amino-3-phosphono-propionic acid (L-AP3). It is suggested that the differential expression of mGluR subtypes might determine their role in brain pathology.
研究了在不同品系大鼠中脑室内（i.h.）和眼内（i.o.）注射选择性代谢型谷氨酸受体（mGluR）激动剂（1S,3R）-1-氨基环戊烷-1,3-二羧酸（1S,3R-ACPD）的作用。在i.h.注射1S,3R-ACPD后7天，观察到CD/SD和Fischer 344大鼠出现大量海马损伤，但SD/Rij和挪威棕色大鼠未出现，而i.o.注射后未观察到视网膜损伤。此外，1S,3R-ACPD降低了CD/SD和SD/Rij大鼠视网膜中的N-甲基-D-天冬氨酸（NMDA）毒性。尽管i.h.注射1S,3R-ACPD对海马神经元有毒性作用，但在CD/SD和SD/Rij大鼠中均引起运动活动的急性刺激。这种作用被脑室内（i.c.v.）注射推定的mGluR拮抗剂L-2-氨基-3-膦酰丙酸（L-AP3）所阻断。提示mGluR亚型的差异表达可能决定它们在脑病理学中的作用。
