Georges B, Blond J P, Maniongui C, Bézard J
Unité de Recherche de Nutrition Cellulaire et Métabolique, Université de Bourgogne, Dijon, France.
Lipids. 1993 Jan;28(1):63-5. doi: 10.1007/BF02536363.
The effect of simvastatin, a hypocholesterolemic drug, on the biosynthesis of arachidonic acid was studied in obese and lean Zucker rats. After administration of 2 mg/kg body weight/d for 13 d, delta 6 and delta 5 desaturase activities were measured in liver microsomes at two substrate concentrations. In untreated rats, the delta 6 desaturation rate was similar in the obese and lean rats when measured at saturating substrate levels, whereas delta 5 desaturation was lower in the obese animals. Treatment with simvastatin did not change delta 6 desaturation in either phenotype but increased delta 5 desaturation in obese rats to reach the unchanged rate observed in lean animals. The changes were not reflected in the fatty acid composition of liver microsomal phospholipids when expressed as micrograms fatty acid/g of liver.
在肥胖和瘦型 Zucker 大鼠中研究了降胆固醇药物辛伐他汀对花生四烯酸生物合成的影响。以 2 毫克/千克体重/天的剂量给药 13 天后，在两种底物浓度下测定肝微粒体中的 Δ6 和 Δ5 去饱和酶活性。在未治疗的大鼠中，在饱和底物水平下测量时，肥胖大鼠和瘦大鼠的 Δ6 去饱和率相似，而肥胖动物的 Δ5 去饱和率较低。辛伐他汀治疗在两种表型中均未改变 Δ6 去饱和，但增加了肥胖大鼠的 Δ5 去饱和，使其达到瘦动物中未改变的速率。当以微克脂肪酸/克肝脏表示时，这些变化未反映在肝微粒体磷脂的脂肪酸组成中。
