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肥胖 Zucker 大鼠肝脏中肉碱酰基转移酶 I 对丙二酰辅酶 A 抑制的高敏感性。

High sensitivity of carnitine acyltransferase I to malonyl-CoA inhibition in liver of obese Zucker rats.

作者信息

Clouet P, Henninger C, Pascal M, Bézard J

出版信息

FEBS Lett. 1985 Mar 25;182(2):331-4. doi: 10.1016/0014-5793(85)80327-6.

DOI:10.1016/0014-5793(85)80327-6
PMID:3979557
Abstract

Carnitine acyltransferase of liver mitochondria prepared from obese Zucker rats has a higher sensitivity to inhibition by malonyl-CoA compared with carnitine acyltransferase of mitochondria prepared from lean Zucker rats.

摘要

与从瘦型 Zucker 大鼠制备的线粒体肉碱酰基转移酶相比，从肥胖 Zucker 大鼠制备的肝脏线粒体肉碱酰基转移酶对丙二酰辅酶 A 的抑制更敏感。

相似文献

1
High sensitivity of carnitine acyltransferase I to malonyl-CoA inhibition in liver of obese Zucker rats.肥胖 Zucker 大鼠肝脏中肉碱酰基转移酶 I 对丙二酰辅酶 A 抑制的高敏感性。
FEBS Lett. 1985 Mar 25;182(2):331-4. doi: 10.1016/0014-5793(85)80327-6.
2
Importance of experimental conditions in evaluating the malonyl-CoA sensitivity of liver carnitine acyltransferase. Studies with fed and starved rats.实验条件在评估肝脏肉碱酰基转移酶丙二酸单酰辅酶A敏感性中的重要性。对喂食和饥饿大鼠的研究。
Biochem J. 1981 Nov 15;200(2):217-23. doi: 10.1042/bj2000217.
3
Effects of fasting and malonyl CoA on the kinetics of carnitine palmitoyltransferase and carnitine octanoyltransferase in intact rat liver mitochondria.禁食和丙二酰辅酶A对完整大鼠肝脏线粒体中肉碱棕榈酰转移酶和肉碱辛酰转移酶动力学的影响。
FEBS Lett. 1981 Sep 28;132(2):166-8. doi: 10.1016/0014-5793(81)81152-0.
4
L-carnitine acyltransferase in intact peroxisomes is inhibited by malonyl-CoA.完整过氧化物酶体中的L-肉碱酰基转移酶受到丙二酸单酰辅酶A的抑制。
Biochem J. 1989 Sep 15;262(3):801-6. doi: 10.1042/bj2620801.
5
Malonyl CoA inhibition of carnitine acyltransferase activities: effects of thiol-group reagents.丙二酰辅酶A对肉碱酰基转移酶活性的抑制作用：硫醇基团试剂的影响
FEBS Lett. 1982 Jan 11;137(1):124-8. doi: 10.1016/0014-5793(82)80329-3.
6
Sensitivity of carnitine acyltransferase I to malonly-CoA inhibition in isolated rat liver mitochondria is quantitatively related to hepatic malonyl-CoA concentration in vivo.在分离的大鼠肝脏线粒体中，肉碱酰基转移酶I对丙二酰辅酶A抑制作用的敏感性与体内肝脏丙二酰辅酶A浓度存在定量关系。
Biochem J. 1982 Jul 15;206(1):177-9. doi: 10.1042/bj2060177.
7
Carnitine palmitoyltransferase I. The site of inhibition of hepatic fatty acid oxidation by malonyl-CoA.肉碱棕榈酰转移酶I。丙二酰辅酶A对肝脏脂肪酸氧化的抑制位点。
J Biol Chem. 1978 Jun 25;253(12):4128-36.
8
The effect of malonyl-CoA on overt and latent carnitine acyltransferase activities in rat liver and adipocyte mitochondria.丙二酰辅酶A对大鼠肝脏和脂肪细胞线粒体中显性和潜在肉碱酰基转移酶活性的影响。
Biochem J. 1983 Feb 15;210(2):591-7. doi: 10.1042/bj2100591.
9
Altered sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA in ketotic diabetic rats.酮症糖尿病大鼠中肉碱棕榈酰转移酶对丙二酰辅酶A抑制作用的敏感性改变。
Biochem J. 1984 Apr 1;219(1):337-9. doi: 10.1042/bj2190337.
10
Increased sensitivity of carnitine palmitoyltransferase I activity to malonyl-CoA inhibition after preincubation of intact rat liver mitochondria with micromolar concentrations of malonyl-CoA in vitro.在体外将完整大鼠肝脏线粒体与微摩尔浓度的丙二酰辅酶A预孵育后，肉碱棕榈酰转移酶I活性对丙二酰辅酶A抑制作用的敏感性增加。
Biochem J. 1983 Mar 15;210(3):953-6. doi: 10.1042/bj2100953.

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Effect of low levels of dietary fish oil on fatty acid desaturation and tissue fatty acids in obese and lean rats.
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Effect of simvastatin on desaturase activities in liver from lean and obese Zucker rats.辛伐他汀对瘦型和肥胖型 Zucker 大鼠肝脏中去饱和酶活性的影响。
Lipids. 1993 Jan;28(1):63-5. doi: 10.1007/BF02536363.
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Effect of dietary n-3 and n-6 polyunsaturated fatty acids on lipid-metabolizing enzymes in obese rat liver.膳食n-3和n-6多不饱和脂肪酸对肥胖大鼠肝脏脂质代谢酶的影响。
Lipids. 1994 Jul;29(7):481-9. doi: 10.1007/BF02578245.
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Hepatic mitochondrial inner-membrane properties, beta-oxidation and carnitine palmitoyltransferases A and B. Effects of genetic obesity and starvation.肝脏线粒体内膜特性、β-氧化以及肉碱棕榈酰转移酶A和B。遗传性肥胖和饥饿的影响。
Biochem J. 1986 Jan 15;233(2):427-33. doi: 10.1042/bj2330427.
7
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Pathway of alpha-linolenic acid through the mitochondrial outer membrane in the rat liver and influence on the rate of oxidation. Comparison with linoleic and oleic acids.大鼠肝脏中α-亚麻酸通过线粒体外膜的途径及其对氧化速率的影响。与亚油酸和油酸的比较。
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