Bennett D R, Powell J G, Rathmacher R P, Shaar C J, Smalstig E B, Cochrane R L
Fertil Steril. 1977 Apr;28(4):464-70. doi: 10.1016/s0015-0282(16)42499-4.
Cortisone acetate (10 mg/day), alone or in combination with progesterone (4 mg/day); progesterone (4 mg/day); progesterone (4 mg/day) plus estrone (1 microng/day); indomethacin (0.75 mg/day); phenylbutazone (20 mg/day); flufenamic acid (10 mg/day); and Compound 83161 (tetrazolo less than 1,5-alpha greater than s-triazolo less than 3,4-c greater than quinoxoline) (8 mg/day and 12 mg/day) were each given to intact rats during early pregnancy (days 1 and/or 2 through day 8). Only cortisone acetate treatment caused a true delay in ovo-implantation. Both progesterone treatment beginning on day 1 and cortisone acetate treatment beginning on day 1 or 2 caused an increased postimplantation fetal death rate. Compound 83161, at doses causing signs of general toxicity (12 mg/day), caused a marginal inhibition of implantation. Treatment with indomethacin, phenylbutazone, or flufenamic acid caused some inhibition of the traumatic deciduomal response in spayed rats treated with progesterone, while treatment with cortisone acetate and Compound 83161 did not.
醋酸可的松（10毫克/天），单独使用或与孕酮（4毫克/天）联合使用；孕酮（4毫克/天）；孕酮（4毫克/天）加雌酮（1微克/天）；吲哚美辛（0.75毫克/天）；保泰松（20毫克/天）；氟芬那酸（10毫克/天）；以及化合物83161（四唑并[1,5-α]三唑并[3,4-c]喹喔啉）（8毫克/天和12毫克/天）在妊娠早期（第1天和/或第2天至第8天）分别给予未切除卵巢的大鼠。只有醋酸可的松治疗导致真正的卵植入延迟。从第1天开始的孕酮治疗以及从第1天或第2天开始的醋酸可的松治疗均导致植入后胎儿死亡率增加。化合物83161在引起全身毒性迹象的剂量（12毫克/天）下对植入有轻微抑制作用。吲哚美辛、保泰松或氟芬那酸治疗对用孕酮处理的去卵巢大鼠的创伤性蜕膜反应有一定抑制作用，而醋酸可的松和化合物83161治疗则没有。
