Carone R, Vercelli D, Bertapelle P
Department of Urology, Spinal Cord Injuries Centre, Torino, Italy.
Paraplegia. 1993 Feb;31(2):125-7. doi: 10.1038/sc.1993.22.
The effect of cisapride on constipation in para and tetraplegia is well known. We have investigated the effects of this prokinetic drug on anorectal activity and on the function of the lower urinary tract. One result of the anorectal study showed a significant increase in activity and a reduction in compliance of the ampulla. The urodynamic study demonstrated earlier and higher amplitude reflex contractions in hyperactive bladders; hypoactive bladders significantly reduced their compliance. No functional alterations of striated urethral sphincter were observed.
西沙必利对截瘫和四肢瘫患者便秘的疗效已广为人知。我们研究了这种促动力药物对肛门直肠活动和下尿路功能的影响。肛门直肠研究的一个结果显示，壶腹活动显著增加，顺应性降低。尿动力学研究表明，膀胱活动亢进患者的反射性收缩更早且幅度更高；膀胱活动减退患者的顺应性显著降低。未观察到横纹肌尿道括约肌的功能改变。
