对乙酰氨基酚的心脏毒性。
Paracetamol cardiotoxicity.
作者信息
Armour A, Slater S D
机构信息
Medical Division, Victoria Infirmary, Glasgow, UK.
出版信息
Postgrad Med J. 1993 Jan;69(807):52-4. doi: 10.1136/pgmj.69.807.52.
Abstract
A 29 year old man with a significant paracetamol overdose was found to have an abnormal electrocardiograph which, in the absence of hepatic encephalopathy, was considered due to a direct cardiotoxic effect of the drug. A functional coronary insufficiency resulting from inhibition of endothelium-derived relaxing factor secondary to depletion of sulphydryl groups is postulated, and it is suggested that in paracetamol poisoning evidence of cardiotoxicity alone may be sufficient justification for treatment with acetylcysteine.
摘要
一名29岁服用大量扑热息痛的男子被发现心电图异常，在没有肝性脑病的情况下，这被认为是该药物直接心脏毒性作用所致。推测是由于巯基耗竭继发内皮源性舒张因子抑制导致功能性冠状动脉供血不足，并且有人提出，在扑热息痛中毒时，仅心脏毒性证据可能就足以成为用乙酰半胱氨酸治疗的充分理由。
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