Boyeson M G, Scherer P J, Grade C M, Krobert K A
Department of Rehabilitation Medicine, University of Wisconsin Medical School, Madison 53706.
Pharmacol Biochem Behav. 1993 Feb;44(2):297-305. doi: 10.1016/0091-3057(93)90465-6.
Previous research has indicated that noradrenergic infusions into the cerebellum contralateral to a sensorimotor cortex injury facilitate recovery of motor function. In the present study, the locus coeruleus was lesioned at 2 weeks prior to, 1 week prior to, or simultaneous with a right sensorimotor cortex injury, and functional recovery in response to noradrenergic cerebellar infusions was measured using the beam-walk task. When the locus coeruleus lesion was separated from the sensorimotor cortex lesion by 1 week or more, noradrenergic-induced facilitation of functional recovery occurred with the greater effects observed at the 2-week interval. Simultaneous locus coeruleus and sensorimotor cortex injury with cerebellar noradrenergic infusions revealed no difference in functional recovery. The results suggest that denervation supersensitivity and/or sprouting developed in the cerebellum following the locus coeruleus lesions if a sufficient amount of time elapsed before the sensorimotor cortex injury. The heightened sensitivity to noradrenergic infusions in the contralateral cerebellum suggests that noradrenergic changes in this structure underlie the acceleration of functional recovery from the cortical injury.
先前的研究表明，向与感觉运动皮层损伤对侧的小脑输注去甲肾上腺素能促进运动功能的恢复。在本研究中，在右侧感觉运动皮层损伤前2周、前1周或同时对蓝斑进行损伤，并使用光束行走任务测量对去甲肾上腺素能小脑输注的功能恢复情况。当蓝斑损伤与感觉运动皮层损伤间隔1周或更长时间时，去甲肾上腺素能诱导的功能恢复促进作用出现，在间隔2周时观察到的效果更明显。蓝斑和感觉运动皮层同时损伤并进行小脑去甲肾上腺素能输注时，功能恢复没有差异。结果表明，如果在感觉运动皮层损伤之前经过足够长的时间，蓝斑损伤后小脑会出现去神经超敏反应和/或发芽。对侧小脑对去甲肾上腺素能输注的敏感性增加表明，该结构中的去甲肾上腺素能变化是皮层损伤后功能恢复加速的基础。
