Terstegge K, Henkes H, Scheuler W, Hansen M L, Ruf B, Kubicki S
Department of Clinical Neurophysiology, Rudolf Virchow University Hospital, Freie Universität Berlin, Germany.
Sleep. 1993 Feb;16(2):137-45. doi: 10.1093/sleep/16.2.137.
Fifteen patients aged between 26 and 55 years with the acquired immunodeficiency syndrome (AIDS) and various cerebral manifestations of the disease underwent an all-night sleep electroencephalogram (EEG) registration. The recordings of 15 age-matched volunteers were examined as controls. Sleep stages were determined visually and the following spectral analysis was based on corresponding artifact-free 40-second periods. The sampling rate was 64 second-1, the spectral resolution was 0.25 Hz and the frequency ranged from 0.25-24 Hz. The power density spectra of eight EEG derivations (left and right frontopolar, frontal, central and occipital; reference montage to the ipsilateral Cb electrodes) and the coherence spectra of interhemispheric (interfrontal, interoccipital) and intrahemispheric (frontooccipital, left and right) channel pairs were computed. The power density of the patients in the 11.5-13-Hz frequency range of nonrapid eye movement (NREM) sleep was considerably lower than that of the controls (p < 0.05 and p < 0.01 at left and right frontal derivations, two-tailed Mann-Whitney U test). The power density of rapid eye movement (REM) sleep showed no consistent differences between the two groups. The interfrontal coherence of the whole frequency range below 12 Hz was markedly lower in the patient group. This applied to NREM sleep and also to REM sleep (p < 0.01 and p < 0.001 for different frequency bands between 1 and 12 Hz in NREM and REM sleep). Possible relations to clinical features are discussed.
15名年龄在26至55岁之间、患有获得性免疫缺陷综合征（AIDS）且有该疾病各种脑部表现的患者接受了整夜睡眠脑电图（EEG）记录。检查了15名年龄匹配的志愿者的记录作为对照。通过视觉确定睡眠阶段，随后的频谱分析基于相应的40秒无伪迹时段。采样率为64秒-1，频谱分辨率为0.25 Hz，频率范围为0.25 - 24 Hz。计算了八个EEG导联（左、右额极、额、中央和枕部；同侧Cb电极作为参考导联）的功率密度谱以及半球间（额间、枕间）和半球内（额枕、左和右）通道对的相干谱。在非快速眼动（NREM）睡眠的11.5 - 13 Hz频率范围内，患者的功率密度显著低于对照组（左、右额导联分别为p < 0.05和p < 0.01，双侧Mann-Whitney U检验）。快速眼动（REM）睡眠的功率密度在两组之间没有一致的差异。患者组中12 Hz以下整个频率范围的额间相干性明显较低。这适用于NREM睡眠，也适用于REM睡眠（NREM和REM睡眠中1至12 Hz不同频段分别为p < 0.01和p < 0.001）。讨论了与临床特征的可能关系。
