Buysse Daniel J, Germain Anne, Hall Martica L, Moul Douglas E, Nofzinger Eric A, Begley Amy, Ehlers Cindy L, Thompson Wesley, Kupfer David J
Neuroscience Clinical and Translational Research Center and Sleep Medicine Institute, University ofPittsburgh School ofMedicine, Pittsburgh, PA, USA.
Sleep. 2008 Dec;31(12):1673-82. doi: 10.1093/sleep/31.12.1673.
To compare NREM EEG power in primary insomnia (PI) and good sleeper controls (GSC), examining both sex and NREM period effects; to examine relationships between EEG power, clinical characteristics, and self-reports of sleep.
Overnight polysomnographic study.
Sleep laboratory.
PI (n=48; 29 women) and GSC (n=25; 15 women).
None.
EEG power from 1-50 Hz was computed for artifact-free sleep epochs across four NREM periods. Repeated measures mixed effect models contrasted differences between groups, EEG frequency bands, and NREM periods. EEG power-frequency curves were modeled using regressions with fixed knot splines.
Mixed models showed no significant group (PI vs. GSC) differences; marginal sex differences (delta and theta bands); significant differences across NREM periods; and groupsex and groupNREM period interactions, particularly in beta and gamma bands. Modeled power-frequency curves showed no group difference in whole-night NREM, but PI had higher power than GSC from 18-40 Hz in the first NREM period. Among women, PI had higher 16 to 44-Hz power than GSC in the first 3 NREM periods, and higher 3 to 5-Hz power across all NREM periods. PI and GSC men showed no consistent differences in EEG power. High-frequency EEG power was not related to clinical or subjective sleep ratings in PI.
Women with PI, but not men, showed increased high-frequency and low-frequency EEG activity during NREM sleep compared to GSC, particularly in early NREM periods. Sex and NREM period may moderate quantitative EEG differences between PI and GSC.
比较原发性失眠（PI）患者和良好睡眠者对照组（GSC）的非快速眼动（NREM）脑电图功率，同时考察性别和NREM时期的影响；研究脑电图功率、临床特征与睡眠自我报告之间的关系。
整夜多导睡眠图研究。
睡眠实验室。
PI组（n = 48；29名女性）和GSC组（n = 25；15名女性）。
无。
计算四个NREM时期无伪迹睡眠时段1 - 50赫兹的脑电图功率。重复测量混合效应模型对比了组间、脑电图频段和NREM时期之间的差异。使用固定节点样条回归对脑电图功率 - 频率曲线进行建模。
混合模型显示无显著的组间（PI组与GSC组）差异；有边缘性的性别差异（δ和θ频段）；NREM时期之间存在显著差异；以及组性别和组NREM时期交互作用，特别是在β和γ频段。建模的功率 - 频率曲线显示整夜NREM中无组间差异，但在第一个NREM时期，PI组在18 - 40赫兹的功率高于GSC组。在女性中，PI组在前3个NREM时期16至44赫兹的功率高于GSC组，且在所有NREM时期3至5赫兹的功率更高。PI组和GSC组男性在脑电图功率上没有一致的差异。PI组中高频脑电图功率与临床或主观睡眠评分无关。
与GSC组相比，PI组女性而非男性在NREM睡眠期间表现出高频和低频脑电图活动增加，特别是在早期NREM时期。性别和NREM时期可能会调节PI组和GSC组之间脑电图的定量差异。
