Meier B
Abteilung für Kardiologie, Inselspital Bern.
Schweiz Med Wochenschr. 1993 Feb 20;123(7):301-10.
Coronary artery disease is the dominant disorder in industrialized countries. It can be treated by drugs, coronary angioplasty, or bypass surgery. Angioplasty has become the most frequent mode of active therapy. Local variations in the use of treatment modalities can be explained mainly by early detection of coronary artery disease yielding more candidates for angioplasty. All indications should be based on a combination of symptoms, objective signs of ischemia (e.g., stress test) and angiographic correlates. Coronary angioplasty is limited to the less complex cases such as single vessel disease (except for diffuse disease, old total occlusions), double vessel disease with up to 3 discrete lesions or lesions in secondary vessels, and, exceptionally, triple vessel disease of the appropriate kind (usually in 2 sessions). These limitations arise from the drawbacks of the method, i.e., acute occlusion (about 7%), recurrence (about 30%), and technical failures (about 5%). For acute myocardial infarction, direct coronary angioplasty is probably the method of choice, provided it can be performed within 30 minutes after diagnosis. For unstable angina, the results are inferior to those obtained with stable symptomatology; compared with the spontaneous prognosis, they remain nonetheless beneficial. The same holds true for angioplasty in elderly patients, where the reduced chances of success must be viewed in light of a typically very severe clinical picture. Angioplasty is often a blessing for young patients. It allows immediate resumption of a normal life and is easily repeatable over the years. Indications for coronary bypass surgery should not be deduced from the randomized studies of the seventies. They concentrated on survival, and surgical methods have been refined since.(ABSTRACT TRUNCATED AT 250 WORDS)
冠状动脉疾病是工业化国家的主要疾病。它可以通过药物、冠状动脉血管成形术或搭桥手术进行治疗。血管成形术已成为最常见的积极治疗方式。治疗方式使用上的地区差异主要可以通过早期发现冠状动脉疾病来解释,这使得更多患者适合接受血管成形术。所有适应症都应基于症状、缺血的客观体征(如负荷试验)以及血管造影相关性的综合判断。冠状动脉血管成形术仅限于不太复杂的病例,如单支血管病变(弥漫性病变、陈旧性完全闭塞除外)、有多达3个离散病变的双支血管病变或次要血管病变,以及特殊情况下合适类型的三支血管病变(通常分两次进行)。这些限制源于该方法的缺点,即急性闭塞(约7%)、复发(约30%)和技术失败(约5%)。对于急性心肌梗死,直接冠状动脉血管成形术可能是首选方法,前提是能在诊断后30分钟内进行。对于不稳定型心绞痛,其结果不如稳定症状时的结果;但与自然预后相比,仍然有益。老年患者接受血管成形术也是如此,鉴于通常非常严重的临床表现,成功机会降低必须加以考虑。血管成形术对年轻患者往往是一件幸事。它能让患者立即恢复正常生活,且多年来易于重复进行。冠状动脉搭桥手术的适应症不应从七十年代的随机研究中推断得出。那些研究集中在生存率上,且自那时以来手术方法已经得到改进。(摘要截选至250词)