Liu D, Andréasson K, Lins P E, Adamson U C, Macdonald I A
Department of Medicine, Karolinska Institute, Danderyd Hospital, Sweden.
Acta Endocrinol (Copenh). 1993 Jan;128(1):95-8. doi: 10.1530/acta.0.1280095.
To compare arterial, arterialized venous and venous measurements of plasma catecholamines during hypoglycaemia, six healthy men were studied by an iv infusion of insulin (1034 pmol.kg-1.h-1). Arterial blood glucose was clamped at the baseline level for the first 30 min and then reduced to 3.2 and to 2.5 mmol/l for 20 min subsequently. At each stage, arterial, arterialized venous and venous blood samples were simultaneously taken for analyses of plasma catecholamines. Plasma glucagon significantly declined during hyperinsulinaemic euglycaemia and then increased during hypoglycaemia. Plasma adrenaline and noradrenaline increased significantly during hypoglycaemia. During euglycaemia and mild hypoglycaemia, arterial adrenaline tended to be higher and arterial noradrenaline lower as compared with the corresponding arterialized and venous values. During marked hypoglycaemia, the arterial catecholamines were significantly higher than that of the two venous samples (p < 0.05). There was a significant correlation between the arterial and the arterialized as well as venous catecholamine values (p < 0.005). We conclude that, during euglycaemia and mild hypoglycaemia, the arterialized adrenaline values are closer to the arterial levels whereas the arterialized noradrenaline concentrations are similar to those measured in venous blood. However, during marked hypoglycaemia, both the arterialized adrenaline and noradrenaline are 20-30% lower than the arterial values, being close to the venous levels.
为比较低血糖期间血浆儿茶酚胺的动脉、动脉化静脉和静脉测量值，对6名健康男性进行了静脉输注胰岛素（1034 pmol·kg⁻¹·h⁻¹）的研究。动脉血糖在前30分钟维持在基线水平，随后20分钟降至3.2 mmol/L和2.5 mmol/L。在每个阶段，同时采集动脉、动脉化静脉和静脉血样用于分析血浆儿茶酚胺。血浆胰高血糖素在高胰岛素正常血糖期间显著下降，然后在低血糖期间升高。血浆肾上腺素和去甲肾上腺素在低血糖期间显著增加。在正常血糖和轻度低血糖期间，与相应的动脉化和静脉值相比，动脉肾上腺素往往较高，动脉去甲肾上腺素较低。在明显低血糖期间，动脉儿茶酚胺显著高于两个静脉样本（p < 0.05）。动脉与动脉化以及静脉儿茶酚胺值之间存在显著相关性（p < 0.005）。我们得出结论，在正常血糖和轻度低血糖期间，动脉化肾上腺素值更接近动脉水平，而动脉化去甲肾上腺素浓度与静脉血中测得的浓度相似。然而，在明显低血糖期间，动脉化肾上腺素和去甲肾上腺素均比动脉值低20% - 30%，接近静脉水平。
