Seino Y, Goto Y, Kurahachi H, Sakurai H, Ikeda M
Horm Metab Res. 1977 Jan;9(1):28-32. doi: 10.1055/s-0028-1093578.
Effect of successful treatment on plasma glucagon response to arginine was studied in patients with diabetes mellitus, Cushing's syndrome and hypothyroidism. Exaggerated response of plasma glucagon to arginine infusion in diabetic subjects was normalized in those successfully treated with sulfonylureas and significantly improved in those treated with insulin. Patients with Cushing's syndrome and hypothyroidism also exhibited excessive responsiveness of plasma glucagon, which were completely normalized following treatment. The results suggest that the metabolic derangement is a main etiologic factor in inducing hyperresponsiveness of plasma glucagon to arginine in these disorders.
在糖尿病、库欣综合征和甲状腺功能减退症患者中研究了成功治疗对血浆胰高血糖素对精氨酸反应的影响。糖尿病患者中，血浆胰高血糖素对精氨酸输注的过度反应在用磺脲类药物成功治疗的患者中恢复正常，在用胰岛素治疗的患者中显著改善。库欣综合征和甲状腺功能减退症患者也表现出血浆胰高血糖素反应过度，治疗后完全恢复正常。结果表明，代谢紊乱是这些疾病中诱导血浆胰高血糖素对精氨酸反应性过高的主要病因。
