Carpentier J, Luyckx A S, Lefebvre P J
Diabete Metab. 1975 Mar;1:23-8.
The insulin and glucagon responses to arginine infusion were investigated in patients with maturity-onset diabetes under control conditions and during metformin therapy. Metformin did not significantly affect the insulin nor the glucagon response to arginine. These data support the concept that biguanide do not act directly on the islets of Langerhans.
在成年发病型糖尿病患者处于对照状态及接受二甲双胍治疗期间，研究了精氨酸输注后的胰岛素和胰高血糖素反应。二甲双胍对精氨酸刺激后的胰岛素及胰高血糖素反应均无显著影响。这些数据支持双胍类药物并非直接作用于胰岛这一观点。
