肝移植后全身血流动力学及氧消耗与早期移植肝失功的关系。
The relationship of systemic hemodynamics and oxygen consumption to early allograft failure after liver transplantation.
作者信息
Takaya S, Nonami T, Selby R, Doyle H, Murray G, Kramer D, Kang Y, Starzl T E
机构信息
Department of Surgery, University of Pittsburgh, PA 15213.
出版信息
Transpl Int. 1993 Mar;6(2):73-6. doi: 10.1007/BF00336648.
The early postoperative hemodynamic data of 88 patients who underwent primary liver transplantation between July 1989 and October 1990 at the University Health Center of Pittsburgh were analyzed to establish the relationship of systemic hemodynamics and oxygen consumption to perioperative allograft function. The 15 patients whose allografts failed within the 1st month following transplantation were designated as group 1, while 73 patients who retained adequate graft function constituted group 2. Although the cardiac index and oxygen delivery did not differ significantly between the groups, group 1 consistently demonstrated a lower mean arterial pressure, oxygen consumption, arteriovenous oxygen content difference, and arterial ketone body ratio. The etiology of reduced oxygen consumption in group 1 patients is speculative, but the data support the notion that oxygen consumption is a useful, predictive indicator for liver allograft function after transplantation.
对1989年7月至1990年10月间在匹兹堡大学健康中心接受初次肝移植的88例患者的术后早期血流动力学数据进行分析，以确定全身血流动力学和氧消耗与围手术期同种异体移植物功能之间的关系。15例移植后1个月内移植物功能衰竭的患者被指定为第1组，而73例保留足够移植物功能的患者构成第2组。尽管两组之间的心指数和氧输送没有显著差异，但第1组始终表现出较低的平均动脉压、氧消耗、动静脉氧含量差和动脉酮体比率。第1组患者氧消耗降低的病因尚属推测，但这些数据支持氧消耗是移植后肝同种异体移植物功能的一个有用的预测指标这一观点。
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