Wong R L, Winslow C M, Cooper K D
Dept of Clinical Research, Sandoz Research Institute, East Hanover, New Jersey 07936.
Immunol Today. 1993 Feb;14(2):69-74. doi: 10.1016/0167-5699(93)90061-o.
This article describes the effects of cyclosporin A (CsA) on the immunopathological mechanisms operative in psoriasis, a human skin disease. The main focus is the effect of CsA on keratinocytes, T cells and antigen-presenting cells, the key players in lesional psoriatic skin. The effect of CsA on other cells, such as neutrophils and endothelial cells, which are important in the maintenance of psoriasis, are also discussed.
本文描述了环孢素A（CsA）对银屑病（一种人类皮肤疾病）中起作用的免疫病理机制的影响。主要关注点是CsA对角质形成细胞、T细胞和抗原呈递细胞的影响，这些是银屑病皮损皮肤中的关键参与者。还讨论了CsA对其他细胞的影响，如在银屑病维持中起重要作用的中性粒细胞和内皮细胞。
