Mattson S N, Carlos R, Riley E P
SDSU/UCSD Joint Doctoral Program in Clinical Psychology, Department of Psychology, San Diego, CA 92120.
Alcohol. 1993 Jan-Feb;10(1):51-7. doi: 10.1016/0741-8329(93)90053-q.
Prenatal alcohol exposure is associated with a variety of developmental abnormalities, including neuroanatomical, physical, and behavioral features. Several mechanisms for alcohol's teratogenic effects have been proposed. This study addresses the role of prostaglandins in the abnormal development that often occurs after maternal alcohol consumption. On gestation days 8 to 18, pregnant Sprague-Dawley rats were prenatally treated with 6 g/kg alcohol following pretreatment with 150 mg/kg aspirin. Behavioral testing of offspring included measures of open-field activity, exploratory behavior, passive avoidance, active avoidance, and acoustic startle response. In most cases, pretreatment with aspirin did not affect performance in alcohol-exposed or control rats.
产前酒精暴露与多种发育异常有关，包括神经解剖学、身体和行为特征。关于酒精致畸作用的几种机制已被提出。本研究探讨了前列腺素在母体饮酒后常发生的异常发育中的作用。在妊娠第8至18天，对怀孕的斯普拉格-道利大鼠在给予150mg/kg阿司匹林预处理后，产前给予6g/kg酒精。对后代的行为测试包括旷场活动、探究行为、被动回避、主动回避和声惊吓反应的测量。在大多数情况下，阿司匹林预处理不影响酒精暴露组或对照组大鼠的行为表现。
