Hannigan J H, Berman R F, Zajac C S
Fetal Alcohol Research Center, Wayne State University School of Medicine, Detroit, MI 48201.
Neurotoxicol Teratol. 1993 Jul-Aug;15(4):261-6. doi: 10.1016/0892-0362(93)90007-b.
Animals exposed prenatally to alcohol (4 g/kg/day) via maternal peroral intubation or control offspring were reared after weaning either alone in standard steel/wire cages or in groups of eight, for 6 weeks. Rats exposed prenatally to alcohol and reared in isolation had a dysmetric stride length indicative of an ataxic gait. However, following postweaning environmental enrichment, prenatal alcohol-exposed rats showed no evidence of ataxia. In addition, the prenatal alcohol-exposed rats showed the same magnitude of improved Morris maze performance after enrichment as did the control offspring. These preliminary results suggest that postnatal environment can influence the expression of alcohol-related birth defects in rats, that rats exposed prenatally to alcohol can benefit from the effects of enriched postweaning environment and that postnatal factors can attenuate some of the deficits due to prenatal alcohol exposure.
通过母体经口插管使动物在产前暴露于酒精（4克/千克/天），或使用对照后代，断奶后将其单独饲养在标准钢/铁丝笼中或每组八只成群饲养6周。产前暴露于酒精并单独饲养的大鼠步幅长度异常，表明存在共济失调步态。然而，断奶后进行环境富集后，产前暴露于酒精的大鼠未表现出共济失调的迹象。此外，产前暴露于酒精的大鼠在富集后，其莫里斯迷宫表现的改善程度与对照后代相同。这些初步结果表明，产后环境可影响大鼠酒精相关出生缺陷的表达，产前暴露于酒精的大鼠可从断奶后丰富环境的影响中受益，且产后因素可减轻部分因产前酒精暴露导致的缺陷。
