Schechter M D, Meehan S M
Department of Pharmacology, Northeastern Ohio Universities, College of Medicine, Rootstown 44272.
Alcohol. 1993 Jan-Feb;10(1):77-81. doi: 10.1016/0741-8329(93)90056-t.
The drug discrimination paradigm was used to evaluate the behavioral differences in response to ethanol between three strains of rats, viz., Sprague-Dawley, N/Nih and Fawn-Hooded. This latter group is thought to have a genetically-transmitted diminished central serotonin function. Each group of rats was trained to discriminate between the stimulus properties of 600 mg/kg ethanol and its vehicle in a two-lever, food-motivated operant task. Results indicate that the Fawn-Hooded rats required a significantly longer time and a higher ethanol dose to reach criterion discrimination performance. Furthermore, the ED50 value of the Fawn-Hooded rats, once trained, was higher than the Sprague-Dawley or N/Nih rats. The possibility that a reciprocal relationship exists between lowered central serotonin concentrations and higher alcohol consumption is suggested and the hypothesis that the diminished ability to recognize the interoceptive stimuli produced by ethanol may result in larger amounts of ethanol being consumed is offered.
药物辨别范式被用于评估三种品系大鼠（即斯普拉格-道利大鼠、N/Nih大鼠和淡褐 hooded 大鼠）对乙醇反应的行为差异。后一组被认为具有遗传传递的中枢5-羟色胺功能减退。每组大鼠在一项双杠杆、以食物为动机的操作性任务中接受训练，以辨别600mg/kg乙醇及其溶媒的刺激特性。结果表明，淡褐 hooded 大鼠达到标准辨别性能所需的时间显著更长，乙醇剂量更高。此外，一旦经过训练，淡褐 hooded 大鼠的半数有效剂量（ED50）值高于斯普拉格-道利大鼠或N/Nih大鼠。研究提出了中枢5-羟色胺浓度降低与更高酒精摄入量之间存在相互关系的可能性，并提出了这样的假设：识别乙醇产生的内感受性刺激的能力减弱可能导致摄入更多量的乙醇。
